Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Jenny Barbier
  • Rolf Jansen
  • Herbert Irschik
  • Stefan Benson
  • Klaus Gerth
  • Bettina Böhlendorf
  • Gerhard Höfle
  • Hans Reichenbach
  • Jens Wegner
  • Carsten Zeilinger
  • Andreas Kirschning
  • Rolf Müller

External Research Organisations

  • Helmholtz Centre for Infection Research (HZI)
  • DSM Food Specialties
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Details

Translated title of the contributionIsolierung und Totalsynthese der Icumazole und Noricumazole – antimykotische Antibiotika und Kationenkanalblocker aus Sorangium cellulosum
Original languageEnglish
Pages (from-to)1256-1260
Number of pages5
JournalAngewandte Chemie
Volume51
Issue number5
Publication statusPublished - 23 Dec 2011

Abstract

Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.

Keywords

    antibiotics, ion-channel inhibitors, myxobacteria, natural products, structure elucidation, total synthesis

ASJC Scopus subject areas

Cite this

Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum. / Barbier, Jenny; Jansen, Rolf; Irschik, Herbert et al.
In: Angewandte Chemie , Vol. 51, No. 5, 23.12.2011, p. 1256-1260.

Research output: Contribution to journalArticleResearchpeer review

Barbier J, Jansen R, Irschik H, Benson S, Gerth K, Böhlendorf B et al. Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum. Angewandte Chemie . 2011 Dec 23;51(5):1256-1260. doi: 10.1002/anie.201106435, https://doi.org/10.1002/ange.201106435, https://doi.org/10.1002/anie.201201953, https://doi.org/10.1002/ange.201201953
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AU - Barbier, Jenny

AU - Jansen, Rolf

AU - Irschik, Herbert

AU - Benson, Stefan

AU - Gerth, Klaus

AU - Böhlendorf, Bettina

AU - Höfle, Gerhard

AU - Reichenbach, Hans

AU - Wegner, Jens

AU - Zeilinger, Carsten

AU - Kirschning, Andreas

AU - Müller, Rolf

PY - 2011/12/23

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KW - ion-channel inhibitors

KW - myxobacteria

KW - natural products

KW - structure elucidation

KW - total synthesis

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