Details
| Translated title of the contribution | Isolierung und Totalsynthese der Icumazole und Noricumazole – antimykotische Antibiotika und Kationenkanalblocker aus Sorangium cellulosum |
|---|---|
| Original language | English |
| Pages (from-to) | 1256-1260 |
| Number of pages | 5 |
| Journal | Angewandte Chemie |
| Volume | 51 |
| Issue number | 5 |
| Publication status | Published - 23 Dec 2011 |
Abstract
Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.
Keywords
- antibiotics, ion-channel inhibitors, myxobacteria, natural products, structure elucidation, total synthesis
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Angewandte Chemie , Vol. 51, No. 5, 23.12.2011, p. 1256-1260.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum
AU - Barbier, Jenny
AU - Jansen, Rolf
AU - Irschik, Herbert
AU - Benson, Stefan
AU - Gerth, Klaus
AU - Böhlendorf, Bettina
AU - Höfle, Gerhard
AU - Reichenbach, Hans
AU - Wegner, Jens
AU - Zeilinger, Carsten
AU - Kirschning, Andreas
AU - Müller, Rolf
PY - 2011/12/23
Y1 - 2011/12/23
N2 - Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.
AB - Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.
KW - antibiotics
KW - ion-channel inhibitors
KW - myxobacteria
KW - natural products
KW - structure elucidation
KW - total synthesis
UR - http://www.scopus.com/inward/record.url?scp=84856159568&partnerID=8YFLogxK
U2 - 10.1002/anie.201106435
DO - 10.1002/anie.201106435
M3 - Article
C2 - 22213143
AN - SCOPUS:84856159568
VL - 51
SP - 1256
EP - 1260
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 5
ER -