Details
| Original language | English |
|---|---|
| Article number | 2000152 |
| Journal | Macromolecular bioscience |
| Volume | 20 |
| Issue number | 9 |
| Publication status | Published - 1 Sept 2020 |
| Externally published | Yes |
Abstract
In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.
Keywords
- drug delivery, hydrogel, ion exchange controlled release, polymerized ionic liquids, sterilization
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Materials Science(all)
- Biomaterials
- Materials Science(all)
- Polymers and Plastics
- Materials Science(all)
- Materials Chemistry
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In: Macromolecular bioscience, Vol. 20, No. 9, 2000152, 01.09.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Ion Exchange Controlled Drug Release from Polymerized Ionic Liquids
AU - Claus, Johanna
AU - Eickner, Thomas
AU - Grabow, Niels
AU - Kragl, Udo
AU - Oschatz, Stefan
N1 - Publisher Copyright: © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/9/1
Y1 - 2020/9/1
N2 - In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.
AB - In this work ion functionalized hydrogels as potent drug delivery systems are presented. The ion functionalization of the hydrogel enables the retention of ionic drug molecules and thus a reduction of burst release effects. Timolol maleate in combination with polymerized anionic 3-sulfopropylmethacrylate potassium and ibuprofen combined with cationic poly-[2-(methacryloyloxy)ethyl] trimethylammonium chloride are investigated in respect to their drug release profile. The results are showing an ion exchange depending release behavior instead of a diffusion-controlled drug release as it is known from common drug delivery systems. Furthermore, the suitability of such hydrogels for standard methods for sterilization is investigated.
KW - drug delivery
KW - hydrogel
KW - ion exchange controlled release
KW - polymerized ionic liquids
KW - sterilization
UR - http://www.scopus.com/inward/record.url?scp=85088130123&partnerID=8YFLogxK
U2 - 10.1002/mabi.202000152
DO - 10.1002/mabi.202000152
M3 - Article
C2 - 32686889
AN - SCOPUS:85088130123
VL - 20
JO - Macromolecular bioscience
JF - Macromolecular bioscience
SN - 1616-5187
IS - 9
M1 - 2000152
ER -