Details
| Original language | English |
|---|---|
| Pages (from-to) | 7-8 |
| Number of pages | 2 |
| Journal | Natural product reports |
| Volume | 40 |
| Issue number | 1 |
| Publication status | Published - 9 Jan 2023 |
Abstract
Filamentous fungi are highly diverse eukaryotes that inhabit all known ecosystems on earth. Estimates suggest that more than 2 × 106 species are likely to exist, and analyses of typical fungal genomes suggest they harbour around 50 biosynthetic gene clusters on average. The biosynthetic potential of these organisms is thus vast. Fungi produce all the main classes of secondary metabolites, and numerous hybrid compounds. Many are highly useful in medicine such as the ‘classic’ special metabolites penicillins, cephalosporins, statins and mycophenolic acid, and new antimicrobial agents such as the pleuromutilins and enfumafungins that overcome specific patterns of resistance. Fungi differentiated from bacteria more than a billion years ago, so there has been plenty of time for uniquely fungal biosynthetic systems to evolve.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Natural product reports, Vol. 40, No. 1, 09.01.2023, p. 7-8.
Research output: Contribution to journal › Editorial in journal › Research › peer review
}
TY - JOUR
T1 - Introduction to engineering the biosynthesis of fungal natural products
AU - Cox, Russell J.
AU - Gulder, Tobias A.M.
PY - 2023/1/9
Y1 - 2023/1/9
N2 - Filamentous fungi are highly diverse eukaryotes that inhabit all known ecosystems on earth. Estimates suggest that more than 2 × 106 species are likely to exist, and analyses of typical fungal genomes suggest they harbour around 50 biosynthetic gene clusters on average. The biosynthetic potential of these organisms is thus vast. Fungi produce all the main classes of secondary metabolites, and numerous hybrid compounds. Many are highly useful in medicine such as the ‘classic’ special metabolites penicillins, cephalosporins, statins and mycophenolic acid, and new antimicrobial agents such as the pleuromutilins and enfumafungins that overcome specific patterns of resistance. Fungi differentiated from bacteria more than a billion years ago, so there has been plenty of time for uniquely fungal biosynthetic systems to evolve.
AB - Filamentous fungi are highly diverse eukaryotes that inhabit all known ecosystems on earth. Estimates suggest that more than 2 × 106 species are likely to exist, and analyses of typical fungal genomes suggest they harbour around 50 biosynthetic gene clusters on average. The biosynthetic potential of these organisms is thus vast. Fungi produce all the main classes of secondary metabolites, and numerous hybrid compounds. Many are highly useful in medicine such as the ‘classic’ special metabolites penicillins, cephalosporins, statins and mycophenolic acid, and new antimicrobial agents such as the pleuromutilins and enfumafungins that overcome specific patterns of resistance. Fungi differentiated from bacteria more than a billion years ago, so there has been plenty of time for uniquely fungal biosynthetic systems to evolve.
UR - http://www.scopus.com/inward/record.url?scp=85146176997&partnerID=8YFLogxK
U2 - 10.1039/d2np90047e
DO - 10.1039/d2np90047e
M3 - Editorial in journal
AN - SCOPUS:85146176997
VL - 40
SP - 7
EP - 8
JO - Natural product reports
JF - Natural product reports
SN - 0265-0568
IS - 1
ER -