Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses

Research output: Chapter in book/report/conference proceedingConference contributionResearchpeer review

Authors

  • Alexander Heisterkamp
  • Tammo Ripken
  • Holger Lubatschowski
  • Herbert Welling
  • Elke Lütkefels
  • Wolfgang Drommer
  • Wolfgang Ertmer

Research Organisations

External Research Organisations

  • Laser Zentrum Hannover e.V. (LZH)
  • University of Veterinary Medicine of Hannover, Foundation
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Details

Original languageEnglish
Title of host publicationOptical Biopsy and Tissue Optics
PublisherSPIE
Pages52-60
Number of pages9
Publication statusPublished - 16 Nov 2000
EventEOS/SPIE European Biomedical Optics Week - Amsterdam, Netherlands
Duration: 4 Jul 20008 Jul 2000

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume4161
ISSN (Print)0277-786X

Abstract

In this work the dependence of the threshold energy and pulse duration for photodisruption was studied between 100 and 1500 femtoseconds using an erbium fibre laser system with subsequent chirped pulse amplification in a titanium-sapphire system. Cutting effects were analysed in animal specimens like rabbit cornea and porcine eye globes. To perform intrastromal cuts, the laser beam was guided through a computer controlled delivery system. The treated tissue was analysed by histological sections and by means of light and electron microscopy. Pressure transients were measured at the endothelium during the cutting procedure. Bubble formation and dynamics were studied using flash photography. The resulting gas bubbles were analysed to their content, and photodissociation could be noticed. As a result of these studies a set of optimised parameters for pulse duration, scanning algorithm, pulse energy and the focusing and beam delivery system could be found. The thermal damage zone in the irradiated tissue was found to be smaller than 1 μm and maximum pressure transients at the endothelium could be determined to be in the range of some hundred millibars. Moreover, performing of intrastromal cuts and creation of a lenticule for achieving a refractive effect in the eye was demonstrated. The investigations show, that fs-pulses are a very precise tool for refractive surgery.

Keywords

    Intrastromal, LASIK, Photodisruption, Refractive surgery, Ultrashort laser pulses

ASJC Scopus subject areas

Cite this

Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses. / Heisterkamp, Alexander; Ripken, Tammo; Lubatschowski, Holger et al.
Optical Biopsy and Tissue Optics. SPIE, 2000. p. 52-60 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 4161).

Research output: Chapter in book/report/conference proceedingConference contributionResearchpeer review

Heisterkamp, A, Ripken, T, Lubatschowski, H, Welling, H, Lütkefels, E, Drommer, W & Ertmer, W 2000, Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses. in Optical Biopsy and Tissue Optics. Proceedings of SPIE - The International Society for Optical Engineering, vol. 4161, SPIE, pp. 52-60, EOS/SPIE European Biomedical Optics Week, Amsterdam, Netherlands, 4 Jul 2000. https://doi.org/10.1117/12.409337
Heisterkamp, A., Ripken, T., Lubatschowski, H., Welling, H., Lütkefels, E., Drommer, W., & Ertmer, W. (2000). Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses. In Optical Biopsy and Tissue Optics (pp. 52-60). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 4161). SPIE. https://doi.org/10.1117/12.409337
Heisterkamp A, Ripken T, Lubatschowski H, Welling H, Lütkefels E, Drommer W et al. Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses. In Optical Biopsy and Tissue Optics. SPIE. 2000. p. 52-60. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.409337
Heisterkamp, Alexander ; Ripken, Tammo ; Lubatschowski, Holger et al. / Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses. Optical Biopsy and Tissue Optics. SPIE, 2000. pp. 52-60 (Proceedings of SPIE - The International Society for Optical Engineering).
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