Details
| Original language | English |
|---|---|
| Title of host publication | Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII |
| Editors | Caroline Boudoux, James W. Tunnell |
| Publisher | SPIE |
| Number of pages | 6 |
| Volume | 12831 |
| ISBN (electronic) | 9781510669215 |
| Publication status | Published - 12 Mar 2024 |
| Event | Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII 2024 - San Francisco, United States Duration: 27 Jan 2024 → 28 Jan 2024 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 12831 |
| ISSN (Print) | 1605-7422 |
Abstract
The rising incidence of skin cancer, in particular melanoma, highlights the need for improved detection techniques. Determining the maximal depth of a lesion is crucial for planning excision margins and optimizing treatment outcomes. However, the current gold standard diagnostics, such as excision and histological examination, are invasive, time-consuming, and may not accurately measure the deepest position of the lesion. Preoperative knowledge of lesion size and depth would greatly assist surgical planning and enhance the likelihood of achieving tumor-free excision margins. In this work, we report on an integrated imaging system that combines ultrasound (US) and photoacoustic tomography (PAT) into a single scanning unit, enabling fast and non-invasive co-localized measurements. Our system facilitates C-mode imaging, providing visualization of lesion depth across its entire size. The design of the setup offers a clear optical window, allowing for integration with other optical modalities. We conducted in vivo measurements on suspicious human skin nevi promptly followed by excision. The combined US/PAT imaging technique demonstrated a strong correlation with histological Breslow thickness, a key parameter for lesion depth. These results highlight the potential of combined US and PAT as a promising non-invasive 3D imaging approach for evaluating human nevi and other skin lesions. By correlating our imaging data with corresponding histological findings, we aim to increase the accuracy and demonstrate the clinical utility of the integrated ultrasound and photoacoustic tomography approach in non-invasive 3D imaging of human melanocytic and other skin lesions.
Keywords
- 3D imaging, multimodal imaging, photoacoustics, skin lesions, ultrasound tomography
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Materials Science(all)
- Biomaterials
- Medicine(all)
- Radiology Nuclear Medicine and imaging
Sustainable Development Goals
Cite this
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Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII. ed. / Caroline Boudoux; James W. Tunnell. Vol. 12831 SPIE, 2024. 128310G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12831).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Integrated ultrasound and photoacoustic tomography for 3D imaging of human skin lesions
AU - Kukk, Anatoly Fedorov
AU - Wu, Di
AU - Panzer, Rüdiger
AU - Emmert, Steffen
AU - Roth, Bernhard
N1 - Publisher Copyright: © 2024 SPIE.
PY - 2024/3/12
Y1 - 2024/3/12
N2 - The rising incidence of skin cancer, in particular melanoma, highlights the need for improved detection techniques. Determining the maximal depth of a lesion is crucial for planning excision margins and optimizing treatment outcomes. However, the current gold standard diagnostics, such as excision and histological examination, are invasive, time-consuming, and may not accurately measure the deepest position of the lesion. Preoperative knowledge of lesion size and depth would greatly assist surgical planning and enhance the likelihood of achieving tumor-free excision margins. In this work, we report on an integrated imaging system that combines ultrasound (US) and photoacoustic tomography (PAT) into a single scanning unit, enabling fast and non-invasive co-localized measurements. Our system facilitates C-mode imaging, providing visualization of lesion depth across its entire size. The design of the setup offers a clear optical window, allowing for integration with other optical modalities. We conducted in vivo measurements on suspicious human skin nevi promptly followed by excision. The combined US/PAT imaging technique demonstrated a strong correlation with histological Breslow thickness, a key parameter for lesion depth. These results highlight the potential of combined US and PAT as a promising non-invasive 3D imaging approach for evaluating human nevi and other skin lesions. By correlating our imaging data with corresponding histological findings, we aim to increase the accuracy and demonstrate the clinical utility of the integrated ultrasound and photoacoustic tomography approach in non-invasive 3D imaging of human melanocytic and other skin lesions.
AB - The rising incidence of skin cancer, in particular melanoma, highlights the need for improved detection techniques. Determining the maximal depth of a lesion is crucial for planning excision margins and optimizing treatment outcomes. However, the current gold standard diagnostics, such as excision and histological examination, are invasive, time-consuming, and may not accurately measure the deepest position of the lesion. Preoperative knowledge of lesion size and depth would greatly assist surgical planning and enhance the likelihood of achieving tumor-free excision margins. In this work, we report on an integrated imaging system that combines ultrasound (US) and photoacoustic tomography (PAT) into a single scanning unit, enabling fast and non-invasive co-localized measurements. Our system facilitates C-mode imaging, providing visualization of lesion depth across its entire size. The design of the setup offers a clear optical window, allowing for integration with other optical modalities. We conducted in vivo measurements on suspicious human skin nevi promptly followed by excision. The combined US/PAT imaging technique demonstrated a strong correlation with histological Breslow thickness, a key parameter for lesion depth. These results highlight the potential of combined US and PAT as a promising non-invasive 3D imaging approach for evaluating human nevi and other skin lesions. By correlating our imaging data with corresponding histological findings, we aim to increase the accuracy and demonstrate the clinical utility of the integrated ultrasound and photoacoustic tomography approach in non-invasive 3D imaging of human melanocytic and other skin lesions.
KW - 3D imaging
KW - multimodal imaging
KW - photoacoustics
KW - skin lesions
KW - ultrasound tomography
UR - http://www.scopus.com/inward/record.url?scp=85194397123&partnerID=8YFLogxK
U2 - 10.1117/12.3001947
DO - 10.1117/12.3001947
M3 - Conference contribution
AN - SCOPUS:85194397123
VL - 12831
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII
A2 - Boudoux, Caroline
A2 - Tunnell, James W.
PB - SPIE
T2 - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII 2024
Y2 - 27 January 2024 through 28 January 2024
ER -