Details
| Original language | English |
|---|---|
| Article number | 464506 |
| Number of pages | 8 |
| Journal | Journal of Chromatography A |
| Volume | 1713 |
| Early online date | 13 Nov 2023 |
| Publication status | Published - 4 Jan 2024 |
Abstract
In this work, the influence of the sample gas flow rate and the ionization region volume of an ion mobility spectrometer (IMS) used as a detector in gas chromatography (GC) on GC-IMS peak shape has been investigated. Therefore, a drift tube IMS with a field-switching ion shutter, a defined ionization region volume and an ultra-violet radiation source was used. To identify the influence of the sample gas flow rate entering the ionization region (equals the GC carrier gas flow rate if no further make-up gas is used) and the ionization region volume on peak broadening and signal intensity, different sample volumes as they would elute from a GC were tested at a variety of sample gas flow rates at a given ionization region volume. The results clearly show that for low sample gas flow rates a depletion of sample molecules in the ionization region leads to a significant decrease in effective detector volume but also to reduced signal intensities. Therefore, for optimal performance of a GC-IMS, the optimal operating point of the GC should match the flow range, where the IMS provides the best compromise between signal-to-noise ratio and peak broadening.
Keywords
- Effective detector volume, GC-IMS, Ionization volume, Peak broadening
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Organic Chemistry
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In: Journal of Chromatography A, Vol. 1713, 464506, 04.01.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Influence of ionization volume and sample gas flow rate on separation power in gas chromatography-ion mobility spectrometry
AU - Kobelt, Tim
AU - Lippmann, Martin
AU - Wuttke, Jannik
AU - Wessel, Hanno
AU - Zimmermann, Stefan
N1 - Funding Information: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – SFB/TRR-298-SIIRI – Project-ID 426335750.
PY - 2024/1/4
Y1 - 2024/1/4
N2 - In this work, the influence of the sample gas flow rate and the ionization region volume of an ion mobility spectrometer (IMS) used as a detector in gas chromatography (GC) on GC-IMS peak shape has been investigated. Therefore, a drift tube IMS with a field-switching ion shutter, a defined ionization region volume and an ultra-violet radiation source was used. To identify the influence of the sample gas flow rate entering the ionization region (equals the GC carrier gas flow rate if no further make-up gas is used) and the ionization region volume on peak broadening and signal intensity, different sample volumes as they would elute from a GC were tested at a variety of sample gas flow rates at a given ionization region volume. The results clearly show that for low sample gas flow rates a depletion of sample molecules in the ionization region leads to a significant decrease in effective detector volume but also to reduced signal intensities. Therefore, for optimal performance of a GC-IMS, the optimal operating point of the GC should match the flow range, where the IMS provides the best compromise between signal-to-noise ratio and peak broadening.
AB - In this work, the influence of the sample gas flow rate and the ionization region volume of an ion mobility spectrometer (IMS) used as a detector in gas chromatography (GC) on GC-IMS peak shape has been investigated. Therefore, a drift tube IMS with a field-switching ion shutter, a defined ionization region volume and an ultra-violet radiation source was used. To identify the influence of the sample gas flow rate entering the ionization region (equals the GC carrier gas flow rate if no further make-up gas is used) and the ionization region volume on peak broadening and signal intensity, different sample volumes as they would elute from a GC were tested at a variety of sample gas flow rates at a given ionization region volume. The results clearly show that for low sample gas flow rates a depletion of sample molecules in the ionization region leads to a significant decrease in effective detector volume but also to reduced signal intensities. Therefore, for optimal performance of a GC-IMS, the optimal operating point of the GC should match the flow range, where the IMS provides the best compromise between signal-to-noise ratio and peak broadening.
KW - Effective detector volume
KW - GC-IMS
KW - Ionization volume
KW - Peak broadening
UR - http://www.scopus.com/inward/record.url?scp=85177182525&partnerID=8YFLogxK
U2 - 10.1016/j.chroma.2023.464506
DO - 10.1016/j.chroma.2023.464506
M3 - Article
C2 - 37983986
AN - SCOPUS:85177182525
VL - 1713
JO - Journal of Chromatography A
JF - Journal of Chromatography A
SN - 0021-9673
M1 - 464506
ER -