Details
| Original language | English |
|---|---|
| Pages (from-to) | 209-216 |
| Number of pages | 8 |
| Journal | Bioprocess Engineering |
| Volume | 10 |
| Issue number | 5-6 |
| Publication status | Published - May 1994 |
Abstract
Pellets of Penicillium chrysogenum which were spontaneously formed after a certain stage of a batch fermentation, displayed a considerable structural change in course of their lifetime. Microelectrode studies showed the internal mass transport properties of these pellets (diameter 1-3 mm) to be highly effected by their morphological structure. Relatively young pellets, in an early stage of the batch fermentation, possessed a homogeneous and dense structure. These pellets were only partly penetrated by oxygen (ca. 70 μm) at air saturated bulk conditions. Older pellets, in a final stage of the batch fermentation, were stratified and fluffy. They were completely penetrated by oxygen due to a decreased activity and a higher diffusivity. Investigations with glucose microelectrodes revealed that glucose consumption inside pellets of all lifetimes exclusively occurred in the periphery, indicating that growth was restricted to these regions only.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
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In: Bioprocess Engineering, Vol. 10, No. 5-6, 05.1994, p. 209-216.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Influence of age and structure of Pencillium chrysogenum pellets on the internal concentration profiles
AU - Cronenberg, C. C.H.
AU - Ottengraf, S. P.P.
AU - van den Heuvel, J. C.
AU - Pottel, F.
AU - Sziele, D.
AU - Schügerl, K.
AU - Bellgardt, K. H.
PY - 1994/5
Y1 - 1994/5
N2 - Pellets of Penicillium chrysogenum which were spontaneously formed after a certain stage of a batch fermentation, displayed a considerable structural change in course of their lifetime. Microelectrode studies showed the internal mass transport properties of these pellets (diameter 1-3 mm) to be highly effected by their morphological structure. Relatively young pellets, in an early stage of the batch fermentation, possessed a homogeneous and dense structure. These pellets were only partly penetrated by oxygen (ca. 70 μm) at air saturated bulk conditions. Older pellets, in a final stage of the batch fermentation, were stratified and fluffy. They were completely penetrated by oxygen due to a decreased activity and a higher diffusivity. Investigations with glucose microelectrodes revealed that glucose consumption inside pellets of all lifetimes exclusively occurred in the periphery, indicating that growth was restricted to these regions only.
AB - Pellets of Penicillium chrysogenum which were spontaneously formed after a certain stage of a batch fermentation, displayed a considerable structural change in course of their lifetime. Microelectrode studies showed the internal mass transport properties of these pellets (diameter 1-3 mm) to be highly effected by their morphological structure. Relatively young pellets, in an early stage of the batch fermentation, possessed a homogeneous and dense structure. These pellets were only partly penetrated by oxygen (ca. 70 μm) at air saturated bulk conditions. Older pellets, in a final stage of the batch fermentation, were stratified and fluffy. They were completely penetrated by oxygen due to a decreased activity and a higher diffusivity. Investigations with glucose microelectrodes revealed that glucose consumption inside pellets of all lifetimes exclusively occurred in the periphery, indicating that growth was restricted to these regions only.
UR - http://www.scopus.com/inward/record.url?scp=0028275642&partnerID=8YFLogxK
U2 - 10.1007/BF00369531
DO - 10.1007/BF00369531
M3 - Article
AN - SCOPUS:0028275642
VL - 10
SP - 209
EP - 216
JO - Bioprocess Engineering
JF - Bioprocess Engineering
SN - 0178-515X
IS - 5-6
ER -