Details
| Original language | English |
|---|---|
| Pages (from-to) | 2427-2440 |
| Number of pages | 14 |
| Journal | Journal of Biomedical Materials Research - Part A |
| Volume | 103 |
| Issue number | 7 |
| Publication status | Published - 23 Dec 2014 |
Abstract
Abstract Magnesium alloys are currently being investigated for use as resorbable biomaterials. Various applications for magnesium based implant materials have already been presented. Currently, stents and structures that sustain diseased or narrowed vessels seem to be the most promising areas. This study focuses on the use of a magnesium fluoride (MgF2) coated magnesium neodymium based alloy (MgNd2) and its use as a postsurgery stent material to avoid proliferation in the sinus region. Simple cylindrical shaped specimens were sown to the sinus' mucosa of pigs and left in place for different periods of time to investigate the long-term corrosion resistance of the alloy and its coating during direct contact with physiological tissue. Investigations made within this study explicitly focused on the corrosive behavior of the alloy in the region of a physiological sinus. Thus, losses in mass and volume, and element analyses were considered to obtain information about the specimens' corrosion performance over time. Furthermore, micrographs support the alloy specific corrosion type analyses which focus on grain boundary effects. This study demonstrates the general in vivo applicability of fluoride coated MgNd2. The progress of corrosion was determined to be adequate and homogeneous over a total period of 180 days.
Keywords
- in vivo corrosion, magnesium, MgF coating, mucosa, neodymium, stent
ASJC Scopus subject areas
- Materials Science(all)
- Ceramics and Composites
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- Metals and Alloys
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In: Journal of Biomedical Materials Research - Part A, Vol. 103, No. 7, 23.12.2014, p. 2427-2440.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - In vivo degradation effects of alloy MgNd2 in contact with mucous tissue
AU - Seitz, J. M.
AU - Eifler, R.
AU - Weber, C.
AU - Lenarz, T. H.
AU - Maier, H. J.
AU - Durisin, M.
PY - 2014/12/23
Y1 - 2014/12/23
N2 - Abstract Magnesium alloys are currently being investigated for use as resorbable biomaterials. Various applications for magnesium based implant materials have already been presented. Currently, stents and structures that sustain diseased or narrowed vessels seem to be the most promising areas. This study focuses on the use of a magnesium fluoride (MgF2) coated magnesium neodymium based alloy (MgNd2) and its use as a postsurgery stent material to avoid proliferation in the sinus region. Simple cylindrical shaped specimens were sown to the sinus' mucosa of pigs and left in place for different periods of time to investigate the long-term corrosion resistance of the alloy and its coating during direct contact with physiological tissue. Investigations made within this study explicitly focused on the corrosive behavior of the alloy in the region of a physiological sinus. Thus, losses in mass and volume, and element analyses were considered to obtain information about the specimens' corrosion performance over time. Furthermore, micrographs support the alloy specific corrosion type analyses which focus on grain boundary effects. This study demonstrates the general in vivo applicability of fluoride coated MgNd2. The progress of corrosion was determined to be adequate and homogeneous over a total period of 180 days.
AB - Abstract Magnesium alloys are currently being investigated for use as resorbable biomaterials. Various applications for magnesium based implant materials have already been presented. Currently, stents and structures that sustain diseased or narrowed vessels seem to be the most promising areas. This study focuses on the use of a magnesium fluoride (MgF2) coated magnesium neodymium based alloy (MgNd2) and its use as a postsurgery stent material to avoid proliferation in the sinus region. Simple cylindrical shaped specimens were sown to the sinus' mucosa of pigs and left in place for different periods of time to investigate the long-term corrosion resistance of the alloy and its coating during direct contact with physiological tissue. Investigations made within this study explicitly focused on the corrosive behavior of the alloy in the region of a physiological sinus. Thus, losses in mass and volume, and element analyses were considered to obtain information about the specimens' corrosion performance over time. Furthermore, micrographs support the alloy specific corrosion type analyses which focus on grain boundary effects. This study demonstrates the general in vivo applicability of fluoride coated MgNd2. The progress of corrosion was determined to be adequate and homogeneous over a total period of 180 days.
KW - in vivo corrosion
KW - magnesium
KW - MgF coating
KW - mucosa
KW - neodymium
KW - stent
UR - http://www.scopus.com/inward/record.url?scp=84930146684&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.35382
DO - 10.1002/jbm.a.35382
M3 - Article
C2 - 25537491
AN - SCOPUS:84930146684
VL - 103
SP - 2427
EP - 2440
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
SN - 1549-3296
IS - 7
ER -