In vitro production of cyclic peptides

Research output: Patent

Inventors

  • Wael Houssen Ibrahim (Inventor)
  • Marcel Jaspars (Inventor)
  • Margaret Smith (Inventor)
  • James Naismith (Inventor)
  • Jesko Koehnke (Inventor)
  • Andrew Bent (Inventor)
  • Nicholas Westwood (Inventor)

Research Organisations

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Details

Original languageEnglish
Patent numberAU2013282973A1
IPCC07K7/64,G01N33/53
Priority date29 Jun 2012
Filing date28 Jun 2013
Publication statusPublished - 5 Feb 2015

Abstract

This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

Cite this

In vitro production of cyclic peptides. / Ibrahim, Wael Houssen (Inventor); Jaspars, Marcel (Inventor); Smith, Margaret (Inventor) et al.
Patent No.: AU2013282973A1. Feb 05, 2015.

Research output: Patent

Ibrahim, WH, Jaspars, M, Smith, M, Naismith, J, Koehnke, J, Bent, A & Westwood, N Feb. 05 2015, In vitro production of cyclic peptides, Patent No. AU2013282973A1. <https://worldwide.espacenet.com/patent/search?q=pn%3DAU2013282973A1>
Ibrahim, W. H., Jaspars, M., Smith, M., Naismith, J., Koehnke, J., Bent, A., & Westwood, N. (2015). In vitro production of cyclic peptides. (Patent No. AU2013282973A1). https://worldwide.espacenet.com/patent/search?q=pn%3DAU2013282973A1
Ibrahim WH, Jaspars M, Smith M, Naismith J, Koehnke J, Bent A et al., inventors. In vitro production of cyclic peptides. AU2013282973A1. 2015 Feb 5.
Ibrahim, Wael Houssen (Inventor) ; Jaspars, Marcel (Inventor) ; Smith, Margaret (Inventor) et al. / In vitro production of cyclic peptides. Patent No.: AU2013282973A1. Feb 05, 2015.
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abstract = "This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.",
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T1 - In vitro production of cyclic peptides

AU - Ibrahim, Wael Houssen

AU - Jaspars, Marcel

AU - Smith, Margaret

AU - Naismith, James

AU - Koehnke, Jesko

AU - Bent, Andrew

AU - Westwood, Nicholas

PY - 2015/2/5

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N2 - This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

AB - This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

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