Details
| Original language | English |
|---|---|
| Article number | 94 |
| Journal | Coatings |
| Volume | 13 |
| Issue number | 1 |
| Publication status | Published - Jan 2023 |
Abstract
Magnesium is a promising metal for resorbable cardiovascular implants due to its high biocompatibility, high corrosion tendency, and mechanical properties. However, adapting its corrosion rate to the physiological healing processes is required to ascertain a safe graft function. A protective polymeric layer is supposed to slow down the corrosion rate of magnesium. Additionally, coatings can improve the host’s tissue interaction with the implant by implementing the local delivery of antibiotic drugs and growth or cell adhesion factors. However, little is known about the interaction of polymer-based coatings, their degradation, and magnesium corrosion. This study examines the corrosion mechanism of magnesium protected by spin coatings and electrospun fiber coatings under physiological conditions. Pure magnesium specimens were coated with polycaprolactone (PCL). The corrosion of the coated magnesium was evaluated using an immersion test in simulated body fluid. Spin coatings provided efficient protection against corrosive attacks and a significantly lower corrosion rate by 75% compared to uncoated magnesium. In contrast, fiber coatings did not provide relevant corrosion protection. On the other hand, magnesium corrosion caused the accelerated degradation of the PCL layer. A reliable and safe implant function is vital, especially in cardiovascular applications. Magnesium coating, therefore, should be carried out with spin coatings.
Keywords
- degradable implants, electrospinning, in vitro testing, magnesium degradation, polymeric coating
ASJC Scopus subject areas
- Physics and Astronomy(all)
- Surfaces and Interfaces
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Materials Chemistry
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In: Coatings, Vol. 13, No. 1, 94, 01.2023.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - In Vitro Investigation of Corrosion Control of Magnesium with Degradable Polycaprolactone Coatings for Cardiovascular Grafts
AU - Knigge, Sara
AU - Mueller, Marc
AU - Fricke, Lara
AU - Schilling, Tobias
AU - Glasmacher, Birgit
N1 - Funding Information: This work was partially supported by the Dr. Jürgen und Irmgard Ulderup Stiftung and Caroline Herschel Program (Equal Opportunities Office) of Leibniz University Hannover. We are grateful to Hans Jürgen Maier from the Institute of Material Science, Leibniz Universität Hannover, who enabled the sample manufacturing. We also thank Svea Doescher for her excellent technical support.
PY - 2023/1
Y1 - 2023/1
N2 - Magnesium is a promising metal for resorbable cardiovascular implants due to its high biocompatibility, high corrosion tendency, and mechanical properties. However, adapting its corrosion rate to the physiological healing processes is required to ascertain a safe graft function. A protective polymeric layer is supposed to slow down the corrosion rate of magnesium. Additionally, coatings can improve the host’s tissue interaction with the implant by implementing the local delivery of antibiotic drugs and growth or cell adhesion factors. However, little is known about the interaction of polymer-based coatings, their degradation, and magnesium corrosion. This study examines the corrosion mechanism of magnesium protected by spin coatings and electrospun fiber coatings under physiological conditions. Pure magnesium specimens were coated with polycaprolactone (PCL). The corrosion of the coated magnesium was evaluated using an immersion test in simulated body fluid. Spin coatings provided efficient protection against corrosive attacks and a significantly lower corrosion rate by 75% compared to uncoated magnesium. In contrast, fiber coatings did not provide relevant corrosion protection. On the other hand, magnesium corrosion caused the accelerated degradation of the PCL layer. A reliable and safe implant function is vital, especially in cardiovascular applications. Magnesium coating, therefore, should be carried out with spin coatings.
AB - Magnesium is a promising metal for resorbable cardiovascular implants due to its high biocompatibility, high corrosion tendency, and mechanical properties. However, adapting its corrosion rate to the physiological healing processes is required to ascertain a safe graft function. A protective polymeric layer is supposed to slow down the corrosion rate of magnesium. Additionally, coatings can improve the host’s tissue interaction with the implant by implementing the local delivery of antibiotic drugs and growth or cell adhesion factors. However, little is known about the interaction of polymer-based coatings, their degradation, and magnesium corrosion. This study examines the corrosion mechanism of magnesium protected by spin coatings and electrospun fiber coatings under physiological conditions. Pure magnesium specimens were coated with polycaprolactone (PCL). The corrosion of the coated magnesium was evaluated using an immersion test in simulated body fluid. Spin coatings provided efficient protection against corrosive attacks and a significantly lower corrosion rate by 75% compared to uncoated magnesium. In contrast, fiber coatings did not provide relevant corrosion protection. On the other hand, magnesium corrosion caused the accelerated degradation of the PCL layer. A reliable and safe implant function is vital, especially in cardiovascular applications. Magnesium coating, therefore, should be carried out with spin coatings.
KW - degradable implants
KW - electrospinning
KW - in vitro testing
KW - magnesium degradation
KW - polymeric coating
UR - http://www.scopus.com/inward/record.url?scp=85146555888&partnerID=8YFLogxK
U2 - 10.3390/coatings13010094
DO - 10.3390/coatings13010094
M3 - Article
AN - SCOPUS:85146555888
VL - 13
JO - Coatings
JF - Coatings
SN - 2079-6412
IS - 1
M1 - 94
ER -