Details
| Original language | English |
|---|---|
| Pages (from-to) | 7765-7768 |
| Number of pages | 4 |
| Journal | Tetrahedron letters |
| Volume | 40 |
| Issue number | 44 |
| Publication status | Published - 29 Oct 1999 |
Abstract
An improved synthesis of the northern hemisphere of epothilone A is described. This approach utilizes the Sharpless asymmetric dihydroxylation of 5-hexen-2-one (allyl acetone) to generate the precursor for the Wittig reaction and the subsequent ring closing metathesis reaction (RCM). This strategy allows to generate precursor 13 as both enantiomers from ready available starting material in a very efficient manner.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Tetrahedron letters, Vol. 40, No. 44, 29.10.1999, p. 7765-7768.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Improved synthesis of the northern hemisphere of epothilone A by a sharpless asymmetric dihydroxylation
AU - Quitschalle, Monika
AU - Kalesse, Markus
PY - 1999/10/29
Y1 - 1999/10/29
N2 - An improved synthesis of the northern hemisphere of epothilone A is described. This approach utilizes the Sharpless asymmetric dihydroxylation of 5-hexen-2-one (allyl acetone) to generate the precursor for the Wittig reaction and the subsequent ring closing metathesis reaction (RCM). This strategy allows to generate precursor 13 as both enantiomers from ready available starting material in a very efficient manner.
AB - An improved synthesis of the northern hemisphere of epothilone A is described. This approach utilizes the Sharpless asymmetric dihydroxylation of 5-hexen-2-one (allyl acetone) to generate the precursor for the Wittig reaction and the subsequent ring closing metathesis reaction (RCM). This strategy allows to generate precursor 13 as both enantiomers from ready available starting material in a very efficient manner.
UR - http://www.scopus.com/inward/record.url?scp=0033615782&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(99)01659-7
DO - 10.1016/S0040-4039(99)01659-7
M3 - Article
AN - SCOPUS:0033615782
VL - 40
SP - 7765
EP - 7768
JO - Tetrahedron letters
JF - Tetrahedron letters
SN - 0040-4039
IS - 44
ER -