Details
| Original language | English |
|---|---|
| Article number | 102289 |
| Journal | Nanomedicine: Nanotechnology, Biology, and Medicine |
| Volume | 30 |
| Early online date | 26 Aug 2020 |
| Publication status | Published - Nov 2020 |
Abstract
Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.
Keywords
- Accumulation, Drug targeting, Implant-associated infection, Magnetic implant
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Medicine(all)
- Medicine (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 30, 102289, 11.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Implant-based direction of magnetic nanoporous silica nanoparticles
T2 - influence of macrophage depletion and infection
AU - Reifenrath, Janin
AU - Janßen, Hilke Catherina
AU - Warwas, Dawid Peter
AU - Kietzmann, Manfred
AU - Behrens, Peter
AU - Willbold, Elmar
AU - Fedchenko, Mykola
AU - Angrisani, Nina
N1 - Funding Information: This work was supported by the German Research Foundation as part of the project “Implant-Directed Magnetic Drug Targeting: Antibiotic therapy of peri-implant infections”, project number: 280642759 . The authors thank Diana Strauch, Mattias Reebmann and Merle Kempfert for excellent technical support. They also thank Silva Holtfreter (University Medicine Greifswald) and Siouxsie Wiles (University of Auckland) for providing the used S. aureus strain. Further thanks go to Mandy Jahns for performing nitrogen physisorption measurements.
PY - 2020/11
Y1 - 2020/11
N2 - Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.
AB - Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.
KW - Accumulation
KW - Drug targeting
KW - Implant-associated infection
KW - Magnetic implant
UR - http://www.scopus.com/inward/record.url?scp=85091061184&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2020.102289
DO - 10.1016/j.nano.2020.102289
M3 - Article
C2 - 32861030
AN - SCOPUS:85091061184
VL - 30
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
M1 - 102289
ER -