Impact of sterilization by electron beam, gamma radiation and X-rays on electrospun poly-(ε-caprolactone) fiber mats

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Dominik de Cassan
  • Anna Lena Hoheisel
  • Birgit Glasmacher
  • Henning Menzel

Research Organisations

External Research Organisations

  • Technische Universität Braunschweig
  • NIFE - Lower Saxony Centre for Biomedical Engineering, Implant Research and Development
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Details

Original languageEnglish
Article number42
JournalJournal of Materials Science: Materials in Medicine
Volume30
Issue number4
Early online date27 Mar 2019
Publication statusPublished - Apr 2019

Abstract

Biodegradable polymers such as polycaprolactone (PCL) are increasingly used for electrospinning substrates for tissue engineering. These materials offer great advantages such as biocompatibility and good mechanical properties. However, in order to be approved for human implantation they have to be sterilized. The impact of commonly used irradiation sterilization methods on electrospun PCL fiber mats was investigated systematically. Electron beam (β-irradiation), gamma and X-ray irradiation with two different doses (25 and 33 kGy) were investigated. To determine the impact on the fiber mats, mechanical, chemical, thermal properties and crystallinity were investigated. Irradiation resulted in a significant decrease in molecular weight. At the same time, crystallinity of fiber mats increased significantly. However, the mechanical properties did not change significantly upon irradiation, mostly likely because effects of a lower molecular weight were balanced with the higher degree of crystallinity. The irradiation effects were dose dependent, a higher irradiation dose led to stronger changes. Gamma irradiation seemed to be the least suited method, while electron beams (β irradiation) had a lower impact. Therefore, β irradiation is recommended as sterilization method for electrospun PCL fiber mats. [Figure not available: see fulltext.].

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Cite this

Impact of sterilization by electron beam, gamma radiation and X-rays on electrospun poly-(ε-caprolactone) fiber mats. / de Cassan, Dominik; Hoheisel, Anna Lena; Glasmacher, Birgit et al.
In: Journal of Materials Science: Materials in Medicine, Vol. 30, No. 4, 42, 04.2019.

Research output: Contribution to journalArticleResearchpeer review

de Cassan D, Hoheisel AL, Glasmacher B, Menzel H. Impact of sterilization by electron beam, gamma radiation and X-rays on electrospun poly-(ε-caprolactone) fiber mats. Journal of Materials Science: Materials in Medicine. 2019 Apr;30(4):42. Epub 2019 Mar 27. doi: 10.1007/s10856-019-6245-7
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title = "Impact of sterilization by electron beam, gamma radiation and X-rays on electrospun poly-(ε-caprolactone) fiber mats",
abstract = "Biodegradable polymers such as polycaprolactone (PCL) are increasingly used for electrospinning substrates for tissue engineering. These materials offer great advantages such as biocompatibility and good mechanical properties. However, in order to be approved for human implantation they have to be sterilized. The impact of commonly used irradiation sterilization methods on electrospun PCL fiber mats was investigated systematically. Electron beam (β-irradiation), gamma and X-ray irradiation with two different doses (25 and 33 kGy) were investigated. To determine the impact on the fiber mats, mechanical, chemical, thermal properties and crystallinity were investigated. Irradiation resulted in a significant decrease in molecular weight. At the same time, crystallinity of fiber mats increased significantly. However, the mechanical properties did not change significantly upon irradiation, mostly likely because effects of a lower molecular weight were balanced with the higher degree of crystallinity. The irradiation effects were dose dependent, a higher irradiation dose led to stronger changes. Gamma irradiation seemed to be the least suited method, while electron beams (β irradiation) had a lower impact. Therefore, β irradiation is recommended as sterilization method for electrospun PCL fiber mats. [Figure not available: see fulltext.].",
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note = "Funding Information: Acknowledgements This research project has been supported by the DFG FOR 2180 “Gradierte Implantate f{\"u}r Sehnen-Knochen-Verbindungen“. Furthermore the authors would like to thank “Th{\"u}nen-Institut f{\"u}r Agrartechnologie” for assistance in performing DSC measurements. The authors would like to thank Michael Bode and Alexander Becker (Institute for Multiphase Processes, Gottfried Wilhelm Leibniz Universit{\"a}t Hannover, Hannover, Germany) for discussions.",
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N1 - Funding Information: Acknowledgements This research project has been supported by the DFG FOR 2180 “Gradierte Implantate für Sehnen-Knochen-Verbindungen“. Furthermore the authors would like to thank “Thünen-Institut für Agrartechnologie” for assistance in performing DSC measurements. The authors would like to thank Michael Bode and Alexander Becker (Institute for Multiphase Processes, Gottfried Wilhelm Leibniz Universität Hannover, Hannover, Germany) for discussions.

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N2 - Biodegradable polymers such as polycaprolactone (PCL) are increasingly used for electrospinning substrates for tissue engineering. These materials offer great advantages such as biocompatibility and good mechanical properties. However, in order to be approved for human implantation they have to be sterilized. The impact of commonly used irradiation sterilization methods on electrospun PCL fiber mats was investigated systematically. Electron beam (β-irradiation), gamma and X-ray irradiation with two different doses (25 and 33 kGy) were investigated. To determine the impact on the fiber mats, mechanical, chemical, thermal properties and crystallinity were investigated. Irradiation resulted in a significant decrease in molecular weight. At the same time, crystallinity of fiber mats increased significantly. However, the mechanical properties did not change significantly upon irradiation, mostly likely because effects of a lower molecular weight were balanced with the higher degree of crystallinity. The irradiation effects were dose dependent, a higher irradiation dose led to stronger changes. Gamma irradiation seemed to be the least suited method, while electron beams (β irradiation) had a lower impact. Therefore, β irradiation is recommended as sterilization method for electrospun PCL fiber mats. [Figure not available: see fulltext.].

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