Details
| Original language | English |
|---|---|
| Pages (from-to) | 4539-4549 |
| Number of pages | 11 |
| Journal | Human brain mapping |
| Volume | 37 |
| Issue number | 12 |
| Publication status | Published - Dec 2016 |
Abstract
Metabolic changes have been suggested to contribute to dementia and its precursor mild cognitive impairment (MCI), yet previous results particularly for the "satiety hormone" leptin are mixed. Therefore, we aimed to determine if MCI patients show systematic differences in leptin, independent of sex, adipose mass, age, and glucose and lipid metabolism, and whether leptin levels correlated with memory performance and hippocampal integrity. Forty MCI patients (20 females, aged 67 years ± 7 SD) were compared to 40 healthy controls (HC) that were pair-wise matched for sex, age, and body fat. Memory performance was assessed using the auditory verbal learning test. Volume and microstructure of the hippocampus were determined using 3T-neuroimaging. Fasting serum markers of leptin, glucose and lipid metabolism, and other confounding factors were assayed. MCI patients, compared with HC, showed lower serum leptin, independent of sex, age, and body fat (P < 0.001). Glucose and lipid markers did not attenuate these results. Moreover, MCI patients exhibited poorer memory and lower volume and microstructural integrity within hippocampal subfields. While leptin and memory were not significantly correlated, mediation analyses indicated that lower leptin contributed to poorer memory through its negative effect on right hippocampus volume and left hippocampus microstructure. We demonstrated that MCI is associated with lower serum leptin independent of sex, age, body fat, glucose, and lipid metabolism. Our data further suggest that inefficient leptin signaling could partly contribute to decreases in memory performance through changes in hippocampus structure, a hypothesis that should now be verified in longitudinal studies. Hum Brain Mapp 37:4539-4549, 2016. © 2016 Wiley Periodicals, Inc.
Keywords
- Aged, Anthropometry, Biomarkers/blood, Blood Glucose, Cognitive Dysfunction/blood, Cross-Sectional Studies, Fasting/blood, Female, Functional Laterality, Hippocampus/diagnostic imaging, Humans, Image Processing, Computer-Assisted, Leptin/blood, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests, Organ Size, hippocampus structure, mediation model, memory performance, leptin, MCI
ASJC Scopus subject areas
- Medicine(all)
- Clinical Neurology
- Neuroscience(all)
- Neurology
- Health Professions(all)
- Radiological and Ultrasound Technology
- Medicine(all)
- Radiology Nuclear Medicine and imaging
- Medicine(all)
- Anatomy
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In: Human brain mapping, Vol. 37, No. 12, 12.2016, p. 4539-4549.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Impact of leptin on memory function and hippocampal structure in mild cognitive impairment
AU - Witte, A. Veronica
AU - Köbe, Theresa
AU - Graunke, Anders
AU - Schuchardt, Jan Philipp
AU - Hahn, Andreas
AU - Tesky, Valentina A
AU - Pantel, Johannes
AU - Flöel, Agnes
N1 - Publisher Copyright: © 2016 Wiley Periodicals, Inc. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/12
Y1 - 2016/12
N2 - Metabolic changes have been suggested to contribute to dementia and its precursor mild cognitive impairment (MCI), yet previous results particularly for the "satiety hormone" leptin are mixed. Therefore, we aimed to determine if MCI patients show systematic differences in leptin, independent of sex, adipose mass, age, and glucose and lipid metabolism, and whether leptin levels correlated with memory performance and hippocampal integrity. Forty MCI patients (20 females, aged 67 years ± 7 SD) were compared to 40 healthy controls (HC) that were pair-wise matched for sex, age, and body fat. Memory performance was assessed using the auditory verbal learning test. Volume and microstructure of the hippocampus were determined using 3T-neuroimaging. Fasting serum markers of leptin, glucose and lipid metabolism, and other confounding factors were assayed. MCI patients, compared with HC, showed lower serum leptin, independent of sex, age, and body fat (P < 0.001). Glucose and lipid markers did not attenuate these results. Moreover, MCI patients exhibited poorer memory and lower volume and microstructural integrity within hippocampal subfields. While leptin and memory were not significantly correlated, mediation analyses indicated that lower leptin contributed to poorer memory through its negative effect on right hippocampus volume and left hippocampus microstructure. We demonstrated that MCI is associated with lower serum leptin independent of sex, age, body fat, glucose, and lipid metabolism. Our data further suggest that inefficient leptin signaling could partly contribute to decreases in memory performance through changes in hippocampus structure, a hypothesis that should now be verified in longitudinal studies. Hum Brain Mapp 37:4539-4549, 2016. © 2016 Wiley Periodicals, Inc.
AB - Metabolic changes have been suggested to contribute to dementia and its precursor mild cognitive impairment (MCI), yet previous results particularly for the "satiety hormone" leptin are mixed. Therefore, we aimed to determine if MCI patients show systematic differences in leptin, independent of sex, adipose mass, age, and glucose and lipid metabolism, and whether leptin levels correlated with memory performance and hippocampal integrity. Forty MCI patients (20 females, aged 67 years ± 7 SD) were compared to 40 healthy controls (HC) that were pair-wise matched for sex, age, and body fat. Memory performance was assessed using the auditory verbal learning test. Volume and microstructure of the hippocampus were determined using 3T-neuroimaging. Fasting serum markers of leptin, glucose and lipid metabolism, and other confounding factors were assayed. MCI patients, compared with HC, showed lower serum leptin, independent of sex, age, and body fat (P < 0.001). Glucose and lipid markers did not attenuate these results. Moreover, MCI patients exhibited poorer memory and lower volume and microstructural integrity within hippocampal subfields. While leptin and memory were not significantly correlated, mediation analyses indicated that lower leptin contributed to poorer memory through its negative effect on right hippocampus volume and left hippocampus microstructure. We demonstrated that MCI is associated with lower serum leptin independent of sex, age, body fat, glucose, and lipid metabolism. Our data further suggest that inefficient leptin signaling could partly contribute to decreases in memory performance through changes in hippocampus structure, a hypothesis that should now be verified in longitudinal studies. Hum Brain Mapp 37:4539-4549, 2016. © 2016 Wiley Periodicals, Inc.
KW - Aged
KW - Anthropometry
KW - Biomarkers/blood
KW - Blood Glucose
KW - Cognitive Dysfunction/blood
KW - Cross-Sectional Studies
KW - Fasting/blood
KW - Female
KW - Functional Laterality
KW - Hippocampus/diagnostic imaging
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Leptin/blood
KW - Longitudinal Studies
KW - Magnetic Resonance Imaging
KW - Male
KW - Memory
KW - Middle Aged
KW - Neuropsychological Tests
KW - Organ Size
KW - hippocampus structure
KW - mediation model
KW - memory performance
KW - leptin
KW - MCI
UR - http://www.scopus.com/inward/record.url?scp=84994234791&partnerID=8YFLogxK
U2 - 10.1002/hbm.23327
DO - 10.1002/hbm.23327
M3 - Article
C2 - 27511061
VL - 37
SP - 4539
EP - 4549
JO - Human brain mapping
JF - Human brain mapping
SN - 1065-9471
IS - 12
ER -