Details
| Original language | English |
|---|---|
| Pages (from-to) | 6528-6535 |
| Number of pages | 8 |
| Journal | International Journal of Pharmacy and Technology |
| Volume | 6 |
| Issue number | 2 |
| Publication status | Published - 1 Jul 2014 |
| Externally published | Yes |
Abstract
In this study, we investigated the secondary metabolic profile of the fungus Fusarium sacchari chromatographically. Fusaric acid and its analogs, fusaric acid methyl ester and 9,10-dehydrofusaric acid were identified and characterised by spectroscopic methods and reported for the first time as secondary metabolites isolated from the fungal extract of F. sacchari. The structure of fusaric acid was fully characterised by x-ray crystallography. Antitumor activity of fusaric acid was tested against larynx cell cancer line (HEP-2), breast cancer cell line (MCF-7), lung cancer cell line (A-549) and colon cancer cell line (HCT-116) and compared with cisplatin as a reference drug. Fusaric acid showed a moderate antitumor activity with IC50 65.9 μM against the HEP-2 cell line.
Keywords
- Antitumor activity, Crystal structure, Fusaric acid, Fusarium sacchari, HPLC
ASJC Scopus subject areas
Sustainable Development Goals
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In: International Journal of Pharmacy and Technology, Vol. 6, No. 2, 01.07.2014, p. 6528-6535.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Identification, Crystal structure and antitumor activity of fusaric acid from the sugarcane fungal pathogen, Fusarium sacchari
AU - Ghannam, Iman A.Y.
AU - Roaiah, Hanaa F.
AU - Hanna, Mona M.
AU - El-Nakkady, Sally S.
AU - Cox, Russell J.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - In this study, we investigated the secondary metabolic profile of the fungus Fusarium sacchari chromatographically. Fusaric acid and its analogs, fusaric acid methyl ester and 9,10-dehydrofusaric acid were identified and characterised by spectroscopic methods and reported for the first time as secondary metabolites isolated from the fungal extract of F. sacchari. The structure of fusaric acid was fully characterised by x-ray crystallography. Antitumor activity of fusaric acid was tested against larynx cell cancer line (HEP-2), breast cancer cell line (MCF-7), lung cancer cell line (A-549) and colon cancer cell line (HCT-116) and compared with cisplatin as a reference drug. Fusaric acid showed a moderate antitumor activity with IC50 65.9 μM against the HEP-2 cell line.
AB - In this study, we investigated the secondary metabolic profile of the fungus Fusarium sacchari chromatographically. Fusaric acid and its analogs, fusaric acid methyl ester and 9,10-dehydrofusaric acid were identified and characterised by spectroscopic methods and reported for the first time as secondary metabolites isolated from the fungal extract of F. sacchari. The structure of fusaric acid was fully characterised by x-ray crystallography. Antitumor activity of fusaric acid was tested against larynx cell cancer line (HEP-2), breast cancer cell line (MCF-7), lung cancer cell line (A-549) and colon cancer cell line (HCT-116) and compared with cisplatin as a reference drug. Fusaric acid showed a moderate antitumor activity with IC50 65.9 μM against the HEP-2 cell line.
KW - Antitumor activity
KW - Crystal structure
KW - Fusaric acid
KW - Fusarium sacchari
KW - HPLC
UR - http://www.scopus.com/inward/record.url?scp=84911384153&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84911384153
VL - 6
SP - 6528
EP - 6535
JO - International Journal of Pharmacy and Technology
JF - International Journal of Pharmacy and Technology
IS - 2
ER -