Details
| Original language | English |
|---|---|
| Pages (from-to) | 150-160 |
| Number of pages | 11 |
| Journal | Journal of functional foods |
| Volume | 7 |
| Issue number | 1 |
| Publication status | Published - 2014 |
Abstract
Tocotrienols are members of the vitamin E family thought to have hypocholesterolaemic, anti-cancer, and neuroprotective properties. We compared the bioavailability and pharmacokinetics of a single oral dose of 450. mg total tocotrienols from α-tocotrienol-rich barley oil and γ-tocotrienol-rich palm oil (both also low in tocopherols) in seven healthy male human subjects 0-24. h post-dose. The maximum α-tocotrienol plasma concentration (22.57. ±. 2.84. mg/L, 2.1. ±. 0.3. h) was significantly ( p<. 0.001) higher for barley oil than for palm oil (5.25. ±. 0.99. mg/L, 2.3. ±. 0.6. h). The area under the curve (0-24. h) of total (α-, β-, γ-, δ-) tocotrienols was significantly ( p<. 0.001) (2.6fold) higher in the barley oil group, where the total (0-24. h) urinary metabolites carboxyethyl-hydroxychromans (CEHC) and carboxymethylbutyl-hydroxychromans (CMBHC) were also significantly ( p<. 0.05) (1.2fold) higher (163.9. ±. 19.2. μmol). Thus, due to its high proportion of α-tocotrienol, which is known for its preferential absorption, the barley oil formulation was superior to the commercial palm oil formulation. This provides support for the application of tocotrienols from barley oil in the functional foods field.
Keywords
- Barley extract, Blood plasma, Human oral bioavailability, Tocotrienol composition, Urinary metabolites, Vitamin E
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Food Science
- Medicine(all)
- Medicine (miscellaneous)
- Nursing(all)
- Nutrition and Dietetics
Sustainable Development Goals
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In: Journal of functional foods, Vol. 7, No. 1, 2014, p. 150-160.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Human oral bioavailability and pharmacokinetics of tocotrienols from tocotrienol-rich (tocopherol-low) barley oil and palm oil formulations
AU - Drotleff, Astrid M.
AU - Bohnsack, C.
AU - Schneider, Inga
AU - Hahn, Andreas
AU - Ternes, Waldemar
N1 - Funding information: This work is part of the “Food Network” project funded by the German Ministry for Science and Culture of Lower Saxony through the Research Association of Agricultural and Nutritional Science of Lower Saxony (Forschungsverbund Agrar- und Ernährungswissenschaften Niedersachsen, FAEN) . The authors also wish to gratefully acknowledge Leiber GmbH (Bramsche, Germany) for their support. Most of all, we would like to thank the participants who contributed their time toward the success of this project.
PY - 2014
Y1 - 2014
N2 - Tocotrienols are members of the vitamin E family thought to have hypocholesterolaemic, anti-cancer, and neuroprotective properties. We compared the bioavailability and pharmacokinetics of a single oral dose of 450. mg total tocotrienols from α-tocotrienol-rich barley oil and γ-tocotrienol-rich palm oil (both also low in tocopherols) in seven healthy male human subjects 0-24. h post-dose. The maximum α-tocotrienol plasma concentration (22.57. ±. 2.84. mg/L, 2.1. ±. 0.3. h) was significantly ( p<. 0.001) higher for barley oil than for palm oil (5.25. ±. 0.99. mg/L, 2.3. ±. 0.6. h). The area under the curve (0-24. h) of total (α-, β-, γ-, δ-) tocotrienols was significantly ( p<. 0.001) (2.6fold) higher in the barley oil group, where the total (0-24. h) urinary metabolites carboxyethyl-hydroxychromans (CEHC) and carboxymethylbutyl-hydroxychromans (CMBHC) were also significantly ( p<. 0.05) (1.2fold) higher (163.9. ±. 19.2. μmol). Thus, due to its high proportion of α-tocotrienol, which is known for its preferential absorption, the barley oil formulation was superior to the commercial palm oil formulation. This provides support for the application of tocotrienols from barley oil in the functional foods field.
AB - Tocotrienols are members of the vitamin E family thought to have hypocholesterolaemic, anti-cancer, and neuroprotective properties. We compared the bioavailability and pharmacokinetics of a single oral dose of 450. mg total tocotrienols from α-tocotrienol-rich barley oil and γ-tocotrienol-rich palm oil (both also low in tocopherols) in seven healthy male human subjects 0-24. h post-dose. The maximum α-tocotrienol plasma concentration (22.57. ±. 2.84. mg/L, 2.1. ±. 0.3. h) was significantly ( p<. 0.001) higher for barley oil than for palm oil (5.25. ±. 0.99. mg/L, 2.3. ±. 0.6. h). The area under the curve (0-24. h) of total (α-, β-, γ-, δ-) tocotrienols was significantly ( p<. 0.001) (2.6fold) higher in the barley oil group, where the total (0-24. h) urinary metabolites carboxyethyl-hydroxychromans (CEHC) and carboxymethylbutyl-hydroxychromans (CMBHC) were also significantly ( p<. 0.05) (1.2fold) higher (163.9. ±. 19.2. μmol). Thus, due to its high proportion of α-tocotrienol, which is known for its preferential absorption, the barley oil formulation was superior to the commercial palm oil formulation. This provides support for the application of tocotrienols from barley oil in the functional foods field.
KW - Barley extract
KW - Blood plasma
KW - Human oral bioavailability
KW - Tocotrienol composition
KW - Urinary metabolites
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=84898047698&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2014.01.001
DO - 10.1016/j.jff.2014.01.001
M3 - Article
VL - 7
SP - 150
EP - 160
JO - Journal of functional foods
JF - Journal of functional foods
SN - 1756-4646
IS - 1
ER -