Details
| Original language | English |
|---|---|
| Pages (from-to) | 1198-1215 |
| Number of pages | 18 |
| Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Volume | 109 |
| Issue number | 8 |
| Early online date | 14 Dec 2020 |
| Publication status | Published - 12 Jun 2021 |
Abstract
Human amniotic membrane (hAM) has been employed as scaffolding material in a wide range of tissue engineering applications, especially as a skin dressing and as a graft for corneal treatment, due to the structure of the extracellular matrix and excellent biological properties that enhance both wound healing and tissue regeneration. This review highlights recent work and current knowledge on the application of native hAM, and/or production of hAM-based tissue-engineered products to create scaffolds mimicking the structure of the native membrane to enhance the hAM performance. Moreover, an overview is presented on the available (cryo) preservation techniques for storage of native hAM and tissue-engineered products that are necessary to maintain biological functions such as angiogenesis, anti-inflammation, antifibrotic and antibacterial activity.
Keywords
- cryopreservation, cryoprotective agent (CPA), extracellular matrix (ECM), human amniotic membrane (hAM), scaffold, tissue engineering (TE)
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- Biomaterials
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In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 109, No. 8, 12.06.2021, p. 1198-1215.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Human Amniotic Membrane
T2 - A review on tissue engineering, application, and storage
AU - Leal-Marin, Sara
AU - Kern, Thomas
AU - Hofmann, Nicola
AU - Pogozhykh, Olena
AU - Framme, Carsten
AU - Borgel, Martin
AU - Figueiredo, Constanca
AU - Glasmacher, Birgit
AU - Gryshkov, Oleksandr
N1 - Funding Information: This work was in part funded by the German Academic Exchange Service (DAAD, 91725466) in the framework of the Research Grants ‐ Doctoral programs in Germany. Open access funding enabled and organized by Projekt DEAL.
PY - 2021/6/12
Y1 - 2021/6/12
N2 - Human amniotic membrane (hAM) has been employed as scaffolding material in a wide range of tissue engineering applications, especially as a skin dressing and as a graft for corneal treatment, due to the structure of the extracellular matrix and excellent biological properties that enhance both wound healing and tissue regeneration. This review highlights recent work and current knowledge on the application of native hAM, and/or production of hAM-based tissue-engineered products to create scaffolds mimicking the structure of the native membrane to enhance the hAM performance. Moreover, an overview is presented on the available (cryo) preservation techniques for storage of native hAM and tissue-engineered products that are necessary to maintain biological functions such as angiogenesis, anti-inflammation, antifibrotic and antibacterial activity.
AB - Human amniotic membrane (hAM) has been employed as scaffolding material in a wide range of tissue engineering applications, especially as a skin dressing and as a graft for corneal treatment, due to the structure of the extracellular matrix and excellent biological properties that enhance both wound healing and tissue regeneration. This review highlights recent work and current knowledge on the application of native hAM, and/or production of hAM-based tissue-engineered products to create scaffolds mimicking the structure of the native membrane to enhance the hAM performance. Moreover, an overview is presented on the available (cryo) preservation techniques for storage of native hAM and tissue-engineered products that are necessary to maintain biological functions such as angiogenesis, anti-inflammation, antifibrotic and antibacterial activity.
KW - cryopreservation
KW - cryoprotective agent (CPA)
KW - extracellular matrix (ECM)
KW - human amniotic membrane (hAM)
KW - scaffold
KW - tissue engineering (TE)
UR - http://www.scopus.com/inward/record.url?scp=85105484664&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.34782
DO - 10.1002/jbm.b.34782
M3 - Review article
VL - 109
SP - 1198
EP - 1215
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
SN - 1552-4973
IS - 8
ER -