Details
| Original language | English |
|---|---|
| Pages (from-to) | 8277–8283 |
| Number of pages | 7 |
| Journal | Analytical chemistry |
| Volume | 95 |
| Issue number | 21 |
| Early online date | 16 May 2023 |
| Publication status | Published - 30 May 2023 |
Abstract
Every drift tube ion mobility spectrometer (IMS) has an optimum drift voltage to reach maximum resolving power. This optimum depends, among other things, on the temporal and spatial width of the injected ion packet and the pressure within the IMS. A reduction of the spatial width of the injected ion packet leads to improved resolving power, higher peak amplitudes when operating the IMS at optimum resolving power, and thus a better signal-to-noise ratio despite the reduced number of injected ions. Hereby, the performance of electrospray ionization (ESI)-IMS can be considerably improved. By setting the ion shutter opening time to just 5 μs and slightly increasing the pressure, a high resolving power RP > 150 can be achieved with a given drift length of just 75 mm. At such high resolving power, even a mixture of the herbicides isoproturon and chlortoluron having similar ion mobility can be well separated despite short drift length.
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
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In: Analytical chemistry, Vol. 95, No. 21, 30.05.2023, p. 8277–8283.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - How to Improve the Resolving Power of Compact Electrospray Ionization Ion Mobility Spectrometers
AU - Thoben, Christian
AU - Raddatz, Christian Robert
AU - Tataroglu, Aykut
AU - Kobelt, Tim
AU - Zimmermann, Stefan
N1 - Funding Information: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)─SFB/TRR-298-SIIRI─Project-ID 426335750. Furthermore, the authors thank Ansgar T. Kirk and Nic Solle for their help during this work.
PY - 2023/5/30
Y1 - 2023/5/30
N2 - Every drift tube ion mobility spectrometer (IMS) has an optimum drift voltage to reach maximum resolving power. This optimum depends, among other things, on the temporal and spatial width of the injected ion packet and the pressure within the IMS. A reduction of the spatial width of the injected ion packet leads to improved resolving power, higher peak amplitudes when operating the IMS at optimum resolving power, and thus a better signal-to-noise ratio despite the reduced number of injected ions. Hereby, the performance of electrospray ionization (ESI)-IMS can be considerably improved. By setting the ion shutter opening time to just 5 μs and slightly increasing the pressure, a high resolving power RP > 150 can be achieved with a given drift length of just 75 mm. At such high resolving power, even a mixture of the herbicides isoproturon and chlortoluron having similar ion mobility can be well separated despite short drift length.
AB - Every drift tube ion mobility spectrometer (IMS) has an optimum drift voltage to reach maximum resolving power. This optimum depends, among other things, on the temporal and spatial width of the injected ion packet and the pressure within the IMS. A reduction of the spatial width of the injected ion packet leads to improved resolving power, higher peak amplitudes when operating the IMS at optimum resolving power, and thus a better signal-to-noise ratio despite the reduced number of injected ions. Hereby, the performance of electrospray ionization (ESI)-IMS can be considerably improved. By setting the ion shutter opening time to just 5 μs and slightly increasing the pressure, a high resolving power RP > 150 can be achieved with a given drift length of just 75 mm. At such high resolving power, even a mixture of the herbicides isoproturon and chlortoluron having similar ion mobility can be well separated despite short drift length.
UR - http://www.scopus.com/inward/record.url?scp=85160765887&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.3c00471
DO - 10.1021/acs.analchem.3c00471
M3 - Article
AN - SCOPUS:85160765887
VL - 95
SP - 8277
EP - 8283
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 21
ER -