Details
| Original language | English |
|---|---|
| Article number | 102516 |
| Number of pages | 10 |
| Journal | Current opinion in microbiology |
| Volume | 80 |
| Early online date | 25 Jul 2024 |
| Publication status | Published - Aug 2024 |
Abstract
Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3′, 5′-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized: the key developmental regulators BldD and σWhiG, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σWhiG, respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Microbiology
- Medicine(all)
- Microbiology (medical)
- Medicine(all)
- Infectious Diseases
Sustainable Development Goals
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In: Current opinion in microbiology, Vol. 80, 102516, 08.2024.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - How c-di-GMP controls progression through the Streptomyces life cycle
AU - Gallagher, Kelley A.
AU - Tschowri, Natalia
AU - Brennan, Richard G.
AU - Schumacher, Maria A.
AU - Buttner, Mark J.
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024/8
Y1 - 2024/8
N2 - Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3′, 5′-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized: the key developmental regulators BldD and σWhiG, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σWhiG, respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
AB - Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3′, 5′-cyclic diguanylic acid (c-di-GMP). So far, three proteins that are directly controlled by c-di-GMP in Streptomyces have been functionally and structurally characterized: the key developmental regulators BldD and σWhiG, and the glycogen-degrading enzyme GlgX. c-di-GMP signals through BldD and σWhiG, respectively, to control the two most dramatic transitions of the Streptomyces life cycle, the formation of the reproductive aerial hyphae and their differentiation into spore chains. Later in development, c-di-GMP activates GlgX-mediated degradation of glycogen, releasing stored carbon for spore maturation.
UR - http://www.scopus.com/inward/record.url?scp=85199460798&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2024.102516
DO - 10.1016/j.mib.2024.102516
M3 - Review article
AN - SCOPUS:85199460798
VL - 80
JO - Current opinion in microbiology
JF - Current opinion in microbiology
SN - 1369-5274
M1 - 102516
ER -