Details
| Original language | English |
|---|---|
| Pages (from-to) | 8680-8684 |
| Number of pages | 5 |
| Journal | ACS catalysis |
| Volume | 8 |
| Issue number | 9 |
| Early online date | 7 Aug 2018 |
| Publication status | Published - 7 Sept 2018 |
| Externally published | Yes |
Abstract
A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.
Keywords
- cofactor regeneration, enzymatic cascades, horse liver alcohol dehydrogenase, lactams, oxidoreductases
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: ACS catalysis, Vol. 8, No. 9, 07.09.2018, p. 8680-8684.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols
AU - Huang, Lei
AU - Sayoga, Giovanni Vallian
AU - Hollmann, Frank
AU - Kara, Selin
N1 - Funding Information: *E-mail: selin.kara@tuhh.de, selin.kara@eng.au.dk (S.K.). ORCID Frank Hollmann: 0000-0003-4821-756X Selin Kara: 0000-0001-6754-2814 Funding S.K. thanks Fonds der Chemischen Industrie (Frankfurt, Germany) for the financial support (Grant No: SK 196/20). L.H. thanks China Scholarship Council (CSC) for the financial support. Notes The authors declare no competing financial interest.
PY - 2018/9/7
Y1 - 2018/9/7
N2 - A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.
AB - A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.
KW - cofactor regeneration
KW - enzymatic cascades
KW - horse liver alcohol dehydrogenase
KW - lactams
KW - oxidoreductases
UR - http://www.scopus.com/inward/record.url?scp=85052392101&partnerID=8YFLogxK
U2 - 10.1021/acscatal.8b02355
DO - 10.1021/acscatal.8b02355
M3 - Article
AN - SCOPUS:85052392101
VL - 8
SP - 8680
EP - 8684
JO - ACS catalysis
JF - ACS catalysis
SN - 2155-5435
IS - 9
ER -