Details
| Original language | English |
|---|---|
| Pages (from-to) | 3019-3022 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 18 |
| Publication status | Published - 29 Feb 2008 |
Abstract
The cross-metathesis of allylestrone with acrylic acid derivatives using homogeneous and heterogenized Ru-catalysts was evaluated for the synthesis of a new 17β-hydroxysteroid dehydrogenase type 1 inhibitor. Hoveyda-type catalyst containing an additional diethylamino group turned out to be comparably active as homogeneous Grubbs II catalyst after immobilization on an acidic ion exchange resin which greatly facilitated workup.
Keywords
- Catalysis, Cross-olefin metathesis, Enzyme inhibitor, Immobilization, Ru-catalyst, Steroids
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Tetrahedron Letters, Vol. 49, No. 18, 29.02.2008, p. 3019-3022.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Homo- and heterogeneous Ru-based metathesis catalysts in cross-metathesis of 15-allylestrone-towards 17β-hydroxysteroid dehydrogenase type 1 inhibitors
AU - Kirschning, Andreas
AU - Harmrolfs, Kirsten
AU - Mennecke, Klaas
AU - Messinger, Josef
AU - Schön, Uwe
AU - Grela, Karol
N1 - Funding information: The work was funded by the Deutsche Forschungsgemeinschaft—Polisch Academy of Sciences joint project ‘Synthetische Nutzung von immobilisierten Ruthenium–Carben–Katalysatoren in Durchflussmikroreaktoren’ (436 POL 113/109/0-1) and the Fonds der Chemischen Industrie.
PY - 2008/2/29
Y1 - 2008/2/29
N2 - The cross-metathesis of allylestrone with acrylic acid derivatives using homogeneous and heterogenized Ru-catalysts was evaluated for the synthesis of a new 17β-hydroxysteroid dehydrogenase type 1 inhibitor. Hoveyda-type catalyst containing an additional diethylamino group turned out to be comparably active as homogeneous Grubbs II catalyst after immobilization on an acidic ion exchange resin which greatly facilitated workup.
AB - The cross-metathesis of allylestrone with acrylic acid derivatives using homogeneous and heterogenized Ru-catalysts was evaluated for the synthesis of a new 17β-hydroxysteroid dehydrogenase type 1 inhibitor. Hoveyda-type catalyst containing an additional diethylamino group turned out to be comparably active as homogeneous Grubbs II catalyst after immobilization on an acidic ion exchange resin which greatly facilitated workup.
KW - Catalysis
KW - Cross-olefin metathesis
KW - Enzyme inhibitor
KW - Immobilization
KW - Ru-catalyst
KW - Steroids
UR - http://www.scopus.com/inward/record.url?scp=41349097890&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2008.02.134
DO - 10.1016/j.tetlet.2008.02.134
M3 - Article
AN - SCOPUS:41349097890
VL - 49
SP - 3019
EP - 3022
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 18
ER -