Details
| Original language | English |
|---|---|
| Pages (from-to) | 6246-6253 |
| Number of pages | 8 |
| Journal | Journal of Physical Chemistry C |
| Volume | 119 |
| Issue number | 11 |
| Publication status | Published - 16 Feb 2015 |
Abstract
Magnetic nanobeads are synthesized by coprecipitation of hollow iron oxide nanoparticles and an amphiphilic polymer. The resulting nanobeads can be tuned in diameter and nanoparticle content. X-ray absorption near-edge structure (XANES) spectroscopy and superconducting quantum interferometer device (SQUID) characterization of the nanobeads reveal that they exhibit an increased effective magnetic anisotropy as compared to the individual nanoparticles, despite that no structural changes of the particles had occurred during the embedding process into the polymer. The spin-spin relaxation times of the pristine hollow nanoparticles and of the final magnetic nanobeads reveal a high R2 relaxivity of 206 s-1 mM-1 for the magnetic nanobeads. This result should enable their application as negative contrast enhancing agents in magnetic resonance imaging.
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Energy(all)
- General Energy
- Chemistry(all)
- Physical and Theoretical Chemistry
- Materials Science(all)
- Surfaces, Coatings and Films
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In: Journal of Physical Chemistry C, Vol. 119, No. 11, 16.02.2015, p. 6246-6253.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Hollow Iron Oxide Nanoparticles in Polymer Nanobeads as MRI Contrast Agents
AU - Bigall, Nadja C.
AU - Dilena, Enrico
AU - Dorfs, Dirk
AU - Beoutis, Marie Lys
AU - Pugliese, Giammarino
AU - Wilhelm, Claire
AU - Gazeau, Florence
AU - Khan, Abid A.
AU - Bittner, Alexander M.
AU - Garcia, Miguel A.
AU - Garcia-Hernandez, Mar
AU - Manna, Liberato
AU - Pellegrino, Teresa
PY - 2015/2/16
Y1 - 2015/2/16
N2 - Magnetic nanobeads are synthesized by coprecipitation of hollow iron oxide nanoparticles and an amphiphilic polymer. The resulting nanobeads can be tuned in diameter and nanoparticle content. X-ray absorption near-edge structure (XANES) spectroscopy and superconducting quantum interferometer device (SQUID) characterization of the nanobeads reveal that they exhibit an increased effective magnetic anisotropy as compared to the individual nanoparticles, despite that no structural changes of the particles had occurred during the embedding process into the polymer. The spin-spin relaxation times of the pristine hollow nanoparticles and of the final magnetic nanobeads reveal a high R2 relaxivity of 206 s-1 mM-1 for the magnetic nanobeads. This result should enable their application as negative contrast enhancing agents in magnetic resonance imaging.
AB - Magnetic nanobeads are synthesized by coprecipitation of hollow iron oxide nanoparticles and an amphiphilic polymer. The resulting nanobeads can be tuned in diameter and nanoparticle content. X-ray absorption near-edge structure (XANES) spectroscopy and superconducting quantum interferometer device (SQUID) characterization of the nanobeads reveal that they exhibit an increased effective magnetic anisotropy as compared to the individual nanoparticles, despite that no structural changes of the particles had occurred during the embedding process into the polymer. The spin-spin relaxation times of the pristine hollow nanoparticles and of the final magnetic nanobeads reveal a high R2 relaxivity of 206 s-1 mM-1 for the magnetic nanobeads. This result should enable their application as negative contrast enhancing agents in magnetic resonance imaging.
UR - http://www.scopus.com/inward/record.url?scp=84925242245&partnerID=8YFLogxK
U2 - 10.1021/jp508951t
DO - 10.1021/jp508951t
M3 - Article
AN - SCOPUS:84925242245
VL - 119
SP - 6246
EP - 6253
JO - Journal of Physical Chemistry C
JF - Journal of Physical Chemistry C
SN - 1932-7447
IS - 11
ER -