Details
| Original language | English |
|---|---|
| Pages (from-to) | 43-51 |
| Number of pages | 9 |
| Journal | Archives of Gynecology and Obstetrics |
| Volume | 296 |
| Issue number | 1 |
| Publication status | Published - 1 Jul 2017 |
Abstract
Purpose: Adequate vitamin D status is crucial for normal development of the fetus and for maternal health. As data on vitamin D status (25-hydroxyvitamin D, 25(OH)D) in German women of different states of pregnancy were not available, this study compared the vitamin D status of German women in all trimesters of pregnancy with that of non-pregnant women. Methods: The study sample of 858 women (18–45 years) was recruited from April 2013 to March 2015 as a part of the cross-sectional Germany-wide VitaMinFemin study. Serum 25(OH)D levels were determined using chemiluminescence immunoassay. Results: A total of 78.1% of the pregnant women and 53.9% of the non-pregnant women had a vitamin D status <50.0 nmol/L (p < 0.001). In pregnant women, the multivariate binary analysis showed that winter [odds ratio (OR) 13.5], longitude of residence between 6.3°E and 8.9°E (OR 2.0) or 9.0°E and 10.9°E (OR 2.3) and third trimester (OR 2.3) were associated with a higher risk of vitamin D status <25.0 nmol/L, whereas increasing age per one year (OR 0.9) with a lower risk. Compared with non-pregnant women, pregnant women were 3.7 times more likely to have a vitamin D status <25.0 nmol/L. Conclusion: A low vitamin D status is prevalent among German pregnant women and should be improved to supply mother and fetus adequately.
Keywords
- 25(OH)D, Germany, Pregnancy, Vitamin D
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynaecology
Sustainable Development Goals
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In: Archives of Gynecology and Obstetrics, Vol. 296, No. 1, 01.07.2017, p. 43-51.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Higher prevalence of vitamin D deficiency in German pregnant women compared to non-pregnant women
AU - Gellert, Sandra
AU - Ströhle, A.
AU - Bitterlich, Norman
AU - Hahn, Andreas
N1 - Funding information: The study was supported by Rottapharm Madaus GmbH (Cologne, Germany) – now a part of Meda AB (Bad Homburg, Germany). The authors are solely responsible for the design and conduct of the study, collection, management, analysis, and interpretation of the data, as well as preparation of the manuscript.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Purpose: Adequate vitamin D status is crucial for normal development of the fetus and for maternal health. As data on vitamin D status (25-hydroxyvitamin D, 25(OH)D) in German women of different states of pregnancy were not available, this study compared the vitamin D status of German women in all trimesters of pregnancy with that of non-pregnant women. Methods: The study sample of 858 women (18–45 years) was recruited from April 2013 to March 2015 as a part of the cross-sectional Germany-wide VitaMinFemin study. Serum 25(OH)D levels were determined using chemiluminescence immunoassay. Results: A total of 78.1% of the pregnant women and 53.9% of the non-pregnant women had a vitamin D status <50.0 nmol/L (p < 0.001). In pregnant women, the multivariate binary analysis showed that winter [odds ratio (OR) 13.5], longitude of residence between 6.3°E and 8.9°E (OR 2.0) or 9.0°E and 10.9°E (OR 2.3) and third trimester (OR 2.3) were associated with a higher risk of vitamin D status <25.0 nmol/L, whereas increasing age per one year (OR 0.9) with a lower risk. Compared with non-pregnant women, pregnant women were 3.7 times more likely to have a vitamin D status <25.0 nmol/L. Conclusion: A low vitamin D status is prevalent among German pregnant women and should be improved to supply mother and fetus adequately.
AB - Purpose: Adequate vitamin D status is crucial for normal development of the fetus and for maternal health. As data on vitamin D status (25-hydroxyvitamin D, 25(OH)D) in German women of different states of pregnancy were not available, this study compared the vitamin D status of German women in all trimesters of pregnancy with that of non-pregnant women. Methods: The study sample of 858 women (18–45 years) was recruited from April 2013 to March 2015 as a part of the cross-sectional Germany-wide VitaMinFemin study. Serum 25(OH)D levels were determined using chemiluminescence immunoassay. Results: A total of 78.1% of the pregnant women and 53.9% of the non-pregnant women had a vitamin D status <50.0 nmol/L (p < 0.001). In pregnant women, the multivariate binary analysis showed that winter [odds ratio (OR) 13.5], longitude of residence between 6.3°E and 8.9°E (OR 2.0) or 9.0°E and 10.9°E (OR 2.3) and third trimester (OR 2.3) were associated with a higher risk of vitamin D status <25.0 nmol/L, whereas increasing age per one year (OR 0.9) with a lower risk. Compared with non-pregnant women, pregnant women were 3.7 times more likely to have a vitamin D status <25.0 nmol/L. Conclusion: A low vitamin D status is prevalent among German pregnant women and should be improved to supply mother and fetus adequately.
KW - 25(OH)D
KW - Germany
KW - Pregnancy
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85019585236&partnerID=8YFLogxK
U2 - 10.1007/s00404-017-4398-5
DO - 10.1007/s00404-017-4398-5
M3 - Article
VL - 296
SP - 43
EP - 51
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
SN - 1432-0711
IS - 1
ER -