Details
| Translated title of the contribution | Induktives Heizen unter Hochfrequenzbedingungen: Anwendung in der kontinuierlichen Synthese des Neuroleptikums Olanzapin (Zyprexa) |
|---|---|
| Original language | English |
| Pages (from-to) | 9813-9817 |
| Number of pages | 5 |
| Journal | Angewandte Chemie |
| Volume | 52 |
| Issue number | 37 |
| Publication status | Published - 24 Jul 2013 |
Abstract
Hot chemistry! High-frequency inductive heating and flow chemistry are an ideal match for high-temperature synthesis. This is demonstrated in the multistep flow synthesis of the neurolepticum olanzapine (Zyprexa) that included three reactions with inductive heating and two purification steps conducted as continuous processes.
Keywords
- Buchwald-Hartwig reaction, flow chemistry, inductive heating, medicinal chemistry, microreactors
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie , Vol. 52, No. 37, 24.07.2013, p. 9813-9817.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Heating under high-frequency inductive conditions
T2 - Application to the continuous synthesis of the neurolepticum olanzapine (Zyprexa)
AU - Hartwig, Jan
AU - Ceylan, Sascha
AU - Kupracz, Lukas
AU - Coutable, Ludovic
AU - Kirschning, Andreas
PY - 2013/7/24
Y1 - 2013/7/24
N2 - Hot chemistry! High-frequency inductive heating and flow chemistry are an ideal match for high-temperature synthesis. This is demonstrated in the multistep flow synthesis of the neurolepticum olanzapine (Zyprexa) that included three reactions with inductive heating and two purification steps conducted as continuous processes.
AB - Hot chemistry! High-frequency inductive heating and flow chemistry are an ideal match for high-temperature synthesis. This is demonstrated in the multistep flow synthesis of the neurolepticum olanzapine (Zyprexa) that included three reactions with inductive heating and two purification steps conducted as continuous processes.
KW - Buchwald-Hartwig reaction
KW - flow chemistry
KW - inductive heating
KW - medicinal chemistry
KW - microreactors
UR - http://www.scopus.com/inward/record.url?scp=84883557350&partnerID=8YFLogxK
U2 - 10.1002/anie.201302239
DO - 10.1002/anie.201302239
M3 - Article
C2 - 23893845
AN - SCOPUS:84883557350
VL - 52
SP - 9813
EP - 9817
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 37
ER -