Details
| Original language | English |
|---|---|
| Pages (from-to) | 1499-1509 |
| Number of pages | 11 |
| Journal | European Journal of Applied Physiology |
| Volume | 113 |
| Issue number | 6 |
| Publication status | Published - Jun 2013 |
| Externally published | Yes |
Abstract
Dehydration and hyperthermia reduces leg blood flow (LBF), cardiac output (Q̇) and arterial pressure during whole-body exercise. It is unknown whether the reductions in blood flow are associated with dehydration-induced alterations in arterial blood oxygen content (CaO2) and O2-dependent signalling. This study investigated the impact of dehydration and concomitant alterations in CaO2 upon LBF and Q̇. Haemodynamics, arterial and femoral venous blood parameters and plasma [ATP] were measured at rest and during one-legged knee-extensor exercise in 7 males in four conditions: (1) control, (2) mild dehydration, (3) moderate dehydration, and (4) rehydration. Relative to control, CaO 2 and LBF increased with dehydration at rest and during exercise (CaO2: from 199 ± 1 to 208 ± 2, and 202 ± 2 to 210 ± 2 ml L-1 and LBF: from 0.38 ± 0.04 to 0.77 ± 0.09, and 1.64 ± 0.09 to 1.88 ± 0.1 L min -1, respectively). Similarly, Q̇ was unchanged or increased with dehydration at rest and during exercise, whereas arterial and leg perfusion pressures declined. Following rehydration, CaO2 declined (to 193 ± 2 mL L-1) but LBF remained elevated. Alterations in LBF were unrelated to CaO2 (r 2 = 0.13-0.27, P = 0.48-0.64) and plasma [ATP]. These findings suggest dehydration and concomitant alterations in CaO2 do not compromise LBF despite reductions in plasma [ATP]. While an additive or synergistic effect cannot be excluded, reductions in LBF during exercise with dehydration may not necessarily be associated with alterations in CaO2 and/or intravascular [ATP].
Keywords
- Cardiovascular control, Dehydration, Leg blood flow, Rehydration
ASJC Scopus subject areas
- Medicine(all)
- Orthopedics and Sports Medicine
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Medicine(all)
- Physiology (medical)
Sustainable Development Goals
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In: European Journal of Applied Physiology, Vol. 113, No. 6, 06.2013, p. 1499-1509.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Haemodynamic responses to dehydration in the resting and exercising human leg
AU - Pearson, James
AU - Kalsi, Kameljit K.
AU - Stöhr, Eric J.
AU - Low, David A.
AU - Barker, Horace
AU - Ali, Leena
AU - González-Alonso, José
N1 - Funding Information: Acknowledgments We would like to thank the participants for their dedication and commitment without which this study would not have been possible. We would also like to acknowledge Dr. Makrand Lotlikar, Orlando Laitano PhD and Mr. Steven Trangmar for their help and assistance during and in preparation for this study. This study was funded by the Gatorade Sports Science Institute.
PY - 2013/6
Y1 - 2013/6
N2 - Dehydration and hyperthermia reduces leg blood flow (LBF), cardiac output (Q̇) and arterial pressure during whole-body exercise. It is unknown whether the reductions in blood flow are associated with dehydration-induced alterations in arterial blood oxygen content (CaO2) and O2-dependent signalling. This study investigated the impact of dehydration and concomitant alterations in CaO2 upon LBF and Q̇. Haemodynamics, arterial and femoral venous blood parameters and plasma [ATP] were measured at rest and during one-legged knee-extensor exercise in 7 males in four conditions: (1) control, (2) mild dehydration, (3) moderate dehydration, and (4) rehydration. Relative to control, CaO 2 and LBF increased with dehydration at rest and during exercise (CaO2: from 199 ± 1 to 208 ± 2, and 202 ± 2 to 210 ± 2 ml L-1 and LBF: from 0.38 ± 0.04 to 0.77 ± 0.09, and 1.64 ± 0.09 to 1.88 ± 0.1 L min -1, respectively). Similarly, Q̇ was unchanged or increased with dehydration at rest and during exercise, whereas arterial and leg perfusion pressures declined. Following rehydration, CaO2 declined (to 193 ± 2 mL L-1) but LBF remained elevated. Alterations in LBF were unrelated to CaO2 (r 2 = 0.13-0.27, P = 0.48-0.64) and plasma [ATP]. These findings suggest dehydration and concomitant alterations in CaO2 do not compromise LBF despite reductions in plasma [ATP]. While an additive or synergistic effect cannot be excluded, reductions in LBF during exercise with dehydration may not necessarily be associated with alterations in CaO2 and/or intravascular [ATP].
AB - Dehydration and hyperthermia reduces leg blood flow (LBF), cardiac output (Q̇) and arterial pressure during whole-body exercise. It is unknown whether the reductions in blood flow are associated with dehydration-induced alterations in arterial blood oxygen content (CaO2) and O2-dependent signalling. This study investigated the impact of dehydration and concomitant alterations in CaO2 upon LBF and Q̇. Haemodynamics, arterial and femoral venous blood parameters and plasma [ATP] were measured at rest and during one-legged knee-extensor exercise in 7 males in four conditions: (1) control, (2) mild dehydration, (3) moderate dehydration, and (4) rehydration. Relative to control, CaO 2 and LBF increased with dehydration at rest and during exercise (CaO2: from 199 ± 1 to 208 ± 2, and 202 ± 2 to 210 ± 2 ml L-1 and LBF: from 0.38 ± 0.04 to 0.77 ± 0.09, and 1.64 ± 0.09 to 1.88 ± 0.1 L min -1, respectively). Similarly, Q̇ was unchanged or increased with dehydration at rest and during exercise, whereas arterial and leg perfusion pressures declined. Following rehydration, CaO2 declined (to 193 ± 2 mL L-1) but LBF remained elevated. Alterations in LBF were unrelated to CaO2 (r 2 = 0.13-0.27, P = 0.48-0.64) and plasma [ATP]. These findings suggest dehydration and concomitant alterations in CaO2 do not compromise LBF despite reductions in plasma [ATP]. While an additive or synergistic effect cannot be excluded, reductions in LBF during exercise with dehydration may not necessarily be associated with alterations in CaO2 and/or intravascular [ATP].
KW - Cardiovascular control
KW - Dehydration
KW - Leg blood flow
KW - Rehydration
UR - http://www.scopus.com/inward/record.url?scp=84878218179&partnerID=8YFLogxK
U2 - 10.1007/s00421-012-2579-2
DO - 10.1007/s00421-012-2579-2
M3 - Article
AN - SCOPUS:84878218179
VL - 113
SP - 1499
EP - 1509
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
SN - 1439-6319
IS - 6
ER -