Details
| Original language | English |
|---|---|
| Pages (from-to) | 896-904 |
| Number of pages | 9 |
| Journal | ACS Applied Nano Materials |
| Volume | 3 |
| Issue number | 1 |
| Early online date | 30 Dec 2019 |
| Publication status | Published - 24 Jan 2020 |
Abstract
Correlating the optical properties to the magnetic properties in superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) will be a boost for future biomedical applications. However, designing such SPIONs without altering its properties is a real challenge. Here, we demonstrate the engineering of the magneto-fluorescent properties simply by tuning the carbon structure in graphitic carbon coated SPIONs. By synthesizing three distinct nanostructures in an easy single step process and studying the in depth structural-functional relationship, we found that the thickness of carbon shell decides the fate of magneto-fluorescent characteristics in SPIONs. Single particle fluorescence data show that the number of emissive photon increases substantially with the increase in the thickness of carbon shell, albeit, the observed relaxivity was enough to get high quality magnetic resonance imaging. The ex vivo magnetic hyperthermia results advanced the use of SPIONs as a single platform for cancer theranostics.
Keywords
- hyperthermia, magnetic resonance imaging, magneto-fluorescent probe, single particle fluorescence imaging, superparamagnetic iron oxide nanoparticles
ASJC Scopus subject areas
- Materials Science(all)
- General Materials Science
Sustainable Development Goals
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In: ACS Applied Nano Materials, Vol. 3, No. 1, 24.01.2020, p. 896-904.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Graphitic Carbon Coated Magnetite Nanoparticles for Dual Mode Imaging and Hyperthermia
AU - Tiwari, Ashish
AU - Verma, Navneet C.
AU - Turkkan, Sibel
AU - Debnath, Ayan
AU - Singh, Anup
AU - Dräger, Gerald
AU - Nandi, Chayan K.
AU - Randhawa, Jaspreet K.
N1 - Funding information: The authors are thankful to IIT Mandi for providing experimental facilities to carry out the research work. The authors also thank Dr. R. K. Gupta from the Fortis Memorial Research Institute for assistance in magnetic resonance scanning. A.S. acknowledges funding support from the SERB project (Grant YSS/2014/000092) for MRI imaging. A.T. acknowledges MHRD for the award of senior research fellowship. N.C.V. thanks the Council of Scientific and Industrial Research (CSIR SRF: 9/1058(07)/17-EMR-1) for the award of senior research fellowship.
PY - 2020/1/24
Y1 - 2020/1/24
N2 - Correlating the optical properties to the magnetic properties in superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) will be a boost for future biomedical applications. However, designing such SPIONs without altering its properties is a real challenge. Here, we demonstrate the engineering of the magneto-fluorescent properties simply by tuning the carbon structure in graphitic carbon coated SPIONs. By synthesizing three distinct nanostructures in an easy single step process and studying the in depth structural-functional relationship, we found that the thickness of carbon shell decides the fate of magneto-fluorescent characteristics in SPIONs. Single particle fluorescence data show that the number of emissive photon increases substantially with the increase in the thickness of carbon shell, albeit, the observed relaxivity was enough to get high quality magnetic resonance imaging. The ex vivo magnetic hyperthermia results advanced the use of SPIONs as a single platform for cancer theranostics.
AB - Correlating the optical properties to the magnetic properties in superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) will be a boost for future biomedical applications. However, designing such SPIONs without altering its properties is a real challenge. Here, we demonstrate the engineering of the magneto-fluorescent properties simply by tuning the carbon structure in graphitic carbon coated SPIONs. By synthesizing three distinct nanostructures in an easy single step process and studying the in depth structural-functional relationship, we found that the thickness of carbon shell decides the fate of magneto-fluorescent characteristics in SPIONs. Single particle fluorescence data show that the number of emissive photon increases substantially with the increase in the thickness of carbon shell, albeit, the observed relaxivity was enough to get high quality magnetic resonance imaging. The ex vivo magnetic hyperthermia results advanced the use of SPIONs as a single platform for cancer theranostics.
KW - hyperthermia
KW - magnetic resonance imaging
KW - magneto-fluorescent probe
KW - single particle fluorescence imaging
KW - superparamagnetic iron oxide nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85078663943&partnerID=8YFLogxK
U2 - 10.1021/acsanm.9b02501
DO - 10.1021/acsanm.9b02501
M3 - Article
AN - SCOPUS:85078663943
VL - 3
SP - 896
EP - 904
JO - ACS Applied Nano Materials
JF - ACS Applied Nano Materials
IS - 1
ER -