Details
| Original language | English |
|---|---|
| Pages (from-to) | 633-641 |
| Number of pages | 9 |
| Journal | International Journal of Artificial Organs |
| Volume | 47 |
| Issue number | 8 |
| Early online date | 8 Aug 2024 |
| Publication status | Published - Aug 2024 |
Abstract
Cardiovascular diseases, particularly myocardial infarction, have significant healthcare challenges due to the limited regenerative capacity of injured heart tissue. Cardiac tissue engineering (CTE) offers a promising approach to repairing myocardial damage using biomaterials that mimic the heart’s extracellular matrix. This study investigates the potential of graphene nanopowder (Gnp)-enhanced polycaprolactone (PCL) scaffolds fabricated via electrospinning to improve the properties necessary for effective cardiac repair. This work aimed to analyze scaffolds with varying graphene concentrations (0.5%, 1%, 1.5%, and 2% by weight) to determine their morphological, chemical, mechanical, and biocompatibility characteristics. The results presented that incorporating graphene improves PCL scaffolds’ mechanical properties and cellular interactions. The optimal concentration of 1% graphene significantly enhanced mechanical properties and biocompatibility, promoting cell adhesion and proliferation. These findings suggest that Gnp-enhanced PCL scaffolds at this concentration can serve as a potent substrate for CTE providing insights into designing more effective biomaterials for myocardial restoration.
Keywords
- biocompatibility, Cardiac tissue engineering (CTE), electrospinning, graphene nanoplatelets (Gnp), myocardial infarction, polycaprolactone (PCL), scaffold
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Medicine(all)
- Medicine (miscellaneous)
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
Sustainable Development Goals
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In: International Journal of Artificial Organs, Vol. 47, No. 8, 08.2024, p. 633-641.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Graphene-enhanced PCL electrospun nanofiber scaffolds for cardiac tissue engineering
AU - Muñoz-Gonzalez, Ana M.
AU - Leal-Marin, Sara
AU - Clavijo-Grimaldo, Dianney
AU - Glasmacher, Birgit
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024/8
Y1 - 2024/8
N2 - Cardiovascular diseases, particularly myocardial infarction, have significant healthcare challenges due to the limited regenerative capacity of injured heart tissue. Cardiac tissue engineering (CTE) offers a promising approach to repairing myocardial damage using biomaterials that mimic the heart’s extracellular matrix. This study investigates the potential of graphene nanopowder (Gnp)-enhanced polycaprolactone (PCL) scaffolds fabricated via electrospinning to improve the properties necessary for effective cardiac repair. This work aimed to analyze scaffolds with varying graphene concentrations (0.5%, 1%, 1.5%, and 2% by weight) to determine their morphological, chemical, mechanical, and biocompatibility characteristics. The results presented that incorporating graphene improves PCL scaffolds’ mechanical properties and cellular interactions. The optimal concentration of 1% graphene significantly enhanced mechanical properties and biocompatibility, promoting cell adhesion and proliferation. These findings suggest that Gnp-enhanced PCL scaffolds at this concentration can serve as a potent substrate for CTE providing insights into designing more effective biomaterials for myocardial restoration.
AB - Cardiovascular diseases, particularly myocardial infarction, have significant healthcare challenges due to the limited regenerative capacity of injured heart tissue. Cardiac tissue engineering (CTE) offers a promising approach to repairing myocardial damage using biomaterials that mimic the heart’s extracellular matrix. This study investigates the potential of graphene nanopowder (Gnp)-enhanced polycaprolactone (PCL) scaffolds fabricated via electrospinning to improve the properties necessary for effective cardiac repair. This work aimed to analyze scaffolds with varying graphene concentrations (0.5%, 1%, 1.5%, and 2% by weight) to determine their morphological, chemical, mechanical, and biocompatibility characteristics. The results presented that incorporating graphene improves PCL scaffolds’ mechanical properties and cellular interactions. The optimal concentration of 1% graphene significantly enhanced mechanical properties and biocompatibility, promoting cell adhesion and proliferation. These findings suggest that Gnp-enhanced PCL scaffolds at this concentration can serve as a potent substrate for CTE providing insights into designing more effective biomaterials for myocardial restoration.
KW - biocompatibility
KW - Cardiac tissue engineering (CTE)
KW - electrospinning
KW - graphene nanoplatelets (Gnp)
KW - myocardial infarction
KW - polycaprolactone (PCL)
KW - scaffold
UR - http://www.scopus.com/inward/record.url?scp=85200948804&partnerID=8YFLogxK
U2 - 10.1177/03913988241266088
DO - 10.1177/03913988241266088
M3 - Article
C2 - 39113566
AN - SCOPUS:85200948804
VL - 47
SP - 633
EP - 641
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
SN - 0391-3988
IS - 8
ER -