Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Anfal Alwan Al-Temimi
  • Aum-El-Bashar Al-Mossawi
  • Sawsan A. Al-Hilifi
  • Sameh A. Korma
  • Tuba Esatbeyoglu
  • João Miguel Rocha
  • Vipul Agarwal

External Research Organisations

  • University of Basrah
  • Zagazig University
  • South China University of Technology
  • Universidade Católica Portuguesa (UCP)
  • University of New South Wales (UNSW)
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Details

Original languageEnglish
Article number465
JournalMetabolites
Volume13
Issue number4
Publication statusPublished - 24 Mar 2023

Abstract

Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death. While glutathione is endogenously present in different plants and animal cells, their concentration varies considerably. The alteration in glutathione homeostasis can be used as a potential marker for human diseases. In the case of the depletion of endogenous glutathione, exogenous sources can be used to replenish the pool. To this end, both natural and synthetic glutathione can be used. However, the health benefit of glutathione from natural sources derived from fruits and vegetables is still debated. There is increasingly growing evidence of the potential health benefits of glutathione in different diseases; however, the determination and in situ quantification of endogenously produced glutathione remains a major challenge. For this reason, it has been difficult to understand the bioprocessing of exogenously delivered glutathione in vivo. The development of an in situ technique will also aid in the routine monitoring of glutathione as a biomarker for different oxidative stress-mediated diseases. Furthermore, an understanding of the in vivo bioprocessing of exogenously delivered glutathione will also aid the food industry both towards improving the longevity and profile of food products and the development of glutathione delivery products for long-term societal health benefits. In this review, we surveyed the natural plant-derived sources of glutathione, the identification and quantification of extracted glutathione from these sources, and the role of glutathione in the food industry and its effect on human health.

Keywords

    bioactive peptides, glutathione, natural peptide, oxidative stress

ASJC Scopus subject areas

Sustainable Development Goals

Cite this

Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review. / Al-Temimi, Anfal Alwan; Al-Mossawi, Aum-El-Bashar; Al-Hilifi, Sawsan A. et al.
In: Metabolites, Vol. 13, No. 4, 465, 24.03.2023.

Research output: Contribution to journalArticleResearchpeer review

Al-Temimi, AA, Al-Mossawi, A-E-B, Al-Hilifi, SA, Korma, SA, Esatbeyoglu, T, Rocha, JM & Agarwal, V 2023, 'Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review', Metabolites, vol. 13, no. 4, 465. https://doi.org/10.3390/metabo13040465
Al-Temimi, A. A., Al-Mossawi, A.-E.-B., Al-Hilifi, S. A., Korma, S. A., Esatbeyoglu, T., Rocha, J. M., & Agarwal, V. (2023). Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review. Metabolites, 13(4), Article 465. https://doi.org/10.3390/metabo13040465
Al-Temimi AA, Al-Mossawi AEB, Al-Hilifi SA, Korma SA, Esatbeyoglu T, Rocha JM et al. Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review. Metabolites. 2023 Mar 24;13(4):465. doi: 10.3390/metabo13040465
Al-Temimi, Anfal Alwan ; Al-Mossawi, Aum-El-Bashar ; Al-Hilifi, Sawsan A. et al. / Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods : A Review. In: Metabolites. 2023 ; Vol. 13, No. 4.
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