Details
| Original language | English |
|---|---|
| Pages (from-to) | 7965-7968 |
| Number of pages | 4 |
| Journal | Chemical communications |
| Volume | 53 |
| Issue number | 56 |
| Publication status | Published - 1 Jan 2017 |
| Externally published | Yes |
Abstract
The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Ceramics and Composites
- Chemistry(all)
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Metals and Alloys
- Materials Science(all)
- Materials Chemistry
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In: Chemical communications, Vol. 53, No. 56, 01.01.2017, p. 7965-7968.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis
AU - Williams, Katherine
AU - Szwalbe, Agnieszka J.
AU - Dickson, Claire
AU - Desson, Tim R.
AU - Mulholland, Nicholas P.
AU - Vincent, Jason L.
AU - Clough, John M.
AU - Bailey, Andrew M.
AU - Butts, Craig P.
AU - Willis, Christine L.
AU - Simpson, Thomas J.
AU - Cox, Russell J.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.
AB - The biosynthesis of the herbicide cornexistin in the fungus Paecilomyces variotii was investigated by full sequencing of its genome, knockout of key genes within its biosynthetic gene cluster and isolation and identification of intermediate compounds. The general biosynthetic pathway resembles that of byssochlamic acid and other nonadrides in the early stages, but differs in requiring fewer enzymes in the key nonadride dimerisation step, and in the removal of one maleic anhydride moiety.
UR - http://www.scopus.com/inward/record.url?scp=85023756550&partnerID=8YFLogxK
U2 - 10.1039/c7cc03303f
DO - 10.1039/c7cc03303f
M3 - Article
C2 - 28660939
AN - SCOPUS:85023756550
VL - 53
SP - 7965
EP - 7968
JO - Chemical communications
JF - Chemical communications
SN - 1359-7345
IS - 56
ER -