Details
| Translated title of the contribution | Whole-genome sequencing in German clinical practice: Economic impacts of its use in selected areas of application |
|---|---|
| Original language | German |
| Pages (from-to) | 143-150 |
| Number of pages | 8 |
| Journal | Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz |
| Volume | 60 |
| Issue number | 2 |
| Early online date | 20 Dec 2016 |
| Publication status | Published - Feb 2017 |
Abstract
Background: The diagnostic use of whole-genome sequencing (WGS) is a growing issue in medical care. Due to limited resources in public health service, budget-impact analyses are necessary prior to implementation. Objective: A budget-impact analysis for WGS of all newborns and diagnostic investigation of tumor patients in different oncologic indications were evaluated. Methods: A cost analysis of WGS based on a quality-assured process chart for WGS at the German Cancer Research Center (DKFZ), Heidelberg, constitutes the basis for this evaluation. Data from the National Association of Statutory Health Insurance Funds and the Robert-Koch-Institute, Berlin, were used for calculations of specific clinical applications. Results and discussion: WGS in newborn screening leads to costs of € 2.85 bn and to an increase of total expenditure by 1.41%. Sequencing of all tumor patients would cost approximately € 0.84 bn, which corresponds to 0.42% of total expenditures. In all scenarios, the sole consideration of procedure costs results in increasing costs. However, in cost discussions potential savings (reduction of disease-related follow-up-costs, improved cost-effectiveness of medical measures etc.) should be considered. Such considerations are the subject of economic indication-specific evaluations. WGS has the potential to generate a large number of deterministic findings for which treatment options are limited. Hence, it is necessary to limit indications, in which WGS has proven medical evidence.
ASJC Scopus subject areas
- Medicine(all)
- Public Health, Environmental and Occupational Health
Sustainable Development Goals
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In: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Vol. 60, No. 2, 02.2017, p. 143-150.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Ganzgenomsequenzierung in der deutschen Versorgung
T2 - Ökonomische Auswirkungen eines Einsatzes in ausgewählten Anwendungsgebieten
AU - Plöthner, Marika
AU - Frank, Martin
AU - Graf von der Schulenburg, J. Matthias
N1 - Publisher Copyright: © 2016, Springer-Verlag Berlin Heidelberg. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - Background: The diagnostic use of whole-genome sequencing (WGS) is a growing issue in medical care. Due to limited resources in public health service, budget-impact analyses are necessary prior to implementation. Objective: A budget-impact analysis for WGS of all newborns and diagnostic investigation of tumor patients in different oncologic indications were evaluated. Methods: A cost analysis of WGS based on a quality-assured process chart for WGS at the German Cancer Research Center (DKFZ), Heidelberg, constitutes the basis for this evaluation. Data from the National Association of Statutory Health Insurance Funds and the Robert-Koch-Institute, Berlin, were used for calculations of specific clinical applications. Results and discussion: WGS in newborn screening leads to costs of € 2.85 bn and to an increase of total expenditure by 1.41%. Sequencing of all tumor patients would cost approximately € 0.84 bn, which corresponds to 0.42% of total expenditures. In all scenarios, the sole consideration of procedure costs results in increasing costs. However, in cost discussions potential savings (reduction of disease-related follow-up-costs, improved cost-effectiveness of medical measures etc.) should be considered. Such considerations are the subject of economic indication-specific evaluations. WGS has the potential to generate a large number of deterministic findings for which treatment options are limited. Hence, it is necessary to limit indications, in which WGS has proven medical evidence.
AB - Background: The diagnostic use of whole-genome sequencing (WGS) is a growing issue in medical care. Due to limited resources in public health service, budget-impact analyses are necessary prior to implementation. Objective: A budget-impact analysis for WGS of all newborns and diagnostic investigation of tumor patients in different oncologic indications were evaluated. Methods: A cost analysis of WGS based on a quality-assured process chart for WGS at the German Cancer Research Center (DKFZ), Heidelberg, constitutes the basis for this evaluation. Data from the National Association of Statutory Health Insurance Funds and the Robert-Koch-Institute, Berlin, were used for calculations of specific clinical applications. Results and discussion: WGS in newborn screening leads to costs of € 2.85 bn and to an increase of total expenditure by 1.41%. Sequencing of all tumor patients would cost approximately € 0.84 bn, which corresponds to 0.42% of total expenditures. In all scenarios, the sole consideration of procedure costs results in increasing costs. However, in cost discussions potential savings (reduction of disease-related follow-up-costs, improved cost-effectiveness of medical measures etc.) should be considered. Such considerations are the subject of economic indication-specific evaluations. WGS has the potential to generate a large number of deterministic findings for which treatment options are limited. Hence, it is necessary to limit indications, in which WGS has proven medical evidence.
KW - Budget-impact analyses
KW - Genetic diagnostics
KW - Newborn screening
KW - Oncology
KW - Whole-genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85006716963&partnerID=8YFLogxK
U2 - 10.1007/s00103-016-2492-7
DO - 10.1007/s00103-016-2492-7
M3 - Artikel
C2 - 27999872
AN - SCOPUS:85006716963
VL - 60
SP - 143
EP - 150
JO - Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
JF - Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
SN - 1436-9990
IS - 2
ER -