Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies

Research output: Contribution to journal › Article › Research › peer review

Authors

  • Esther Vázquez
  • José L. Corchero
  • Joan F. Burgueño
  • Joaquin Seras-Franzoso
  • Ana Kosoy
  • Ramon Bosser
  • Rosa Mendoza
  • Joan Marc Martínez-Láinez
  • Ursula Rinas
  • Ester Fernández
  • Luis Ruiz-Avila
  • Elena García-Fruitõs
  • Antonio Villaverde

Research Organisations

External Research Organisations

  • Autonomous University of Barcelona (UAB)
  • Centros de Investigacion Biomedica en Red - CIBER
  • Janus Development, SL
  • Helmholtz Centre for Infection Research (HZI)
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Details

Original languageEnglish
Pages (from-to)1742-1747
Number of pages6
JournalAdvanced materials
Volume24
Issue number13
Early online date13 Mar 2012
Publication statusPublished - 3 Apr 2012

Abstract

Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.

Keywords

    cell therapy, nanomedicine, nanopills, protein particles, recombinant proteins

ASJC Scopus subject areas

Cite this

Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies. / Vázquez, Esther; Corchero, José L.; Burgueño, Joan F. et al.
In: Advanced materials, Vol. 24, No. 13, 03.04.2012, p. 1742-1747.

Research output: Contribution to journal › Article › Research › peer review

Vázquez, E, Corchero, JL, Burgueño, JF, Seras-Franzoso, J, Kosoy, A, Bosser, R, Mendoza, R, Martínez-Láinez, JM, Rinas, U, Fernández, E, Ruiz-Avila, L, García-Fruitõs, E & Villaverde, A 2012, 'Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies', Advanced materials, vol. 24, no. 13, pp. 1742-1747. https://doi.org/10.1002/adma.201104330
Vázquez, E., Corchero, J. L., Burgueño, J. F., Seras-Franzoso, J., Kosoy, A., Bosser, R., Mendoza, R., Martínez-Láinez, J. M., Rinas, U., Fernández, E., Ruiz-Avila, L., García-Fruitõs, E., & Villaverde, A. (2012). Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies. Advanced materials, 24(13), 1742-1747. https://doi.org/10.1002/adma.201104330
Vázquez E, Corchero JL, Burgueño JF, Seras-Franzoso J, Kosoy A, Bosser R et al. Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies. Advanced materials. 2012 Apr 3;24(13):1742-1747. Epub 2012 Mar 13. doi: 10.1002/adma.201104330
Vázquez, Esther ; Corchero, José L. ; Burgueño, Joan F. et al. / Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies. In: Advanced materials. 2012 ; Vol. 24, No. 13. pp. 1742-1747.
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