Details
| Original language | English |
|---|---|
| Pages (from-to) | 522-528 |
| Number of pages | 7 |
| Journal | Journal of Materials Chemistry B |
| Volume | 1 |
| Issue number | 4 |
| Publication status | Published - 9 Nov 2012 |
Abstract
Here we report the preparation, characterization and application of folic acid modified Montmorillonite clay (FA-Mont) as a cell culture material. Clays exhibit unique properties such as good mechanical and chemical stabilities, high surface area, low toxicity and easy combination with functional organic groups. FA was used as a modifier to facilitate adhesion of folate positive cells on the clay surface. FA-Mont was characterized using FT-IR, XRD, zeta potential measurements as well as thermogravimetric analyses. Finally, the usage potential of FA-Mont as a receptor mediated cell adhesion material was successfully proved by using folate receptor (FR) rich HeLa and FR poor A-549 cells. The cell adhesion studies were monitored and imaged by fluorescence and scanning electron microscopy techniques.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- General Materials Science
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In: Journal of Materials Chemistry B, Vol. 1, No. 4, 09.11.2012, p. 522-528.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Folic acid-modified clay
T2 - targeted surface design for cell culture applications
AU - Bongartz, Rebecca
AU - Ag, Didem
AU - Seleci, Muharrem
AU - Walter, Johanna G.
AU - Yalcinkaya, Esra E.
AU - Demirkol, Dilek Odaci
AU - Stahl, Frank
AU - Timur, Suna
AU - Scheper, Thomas
PY - 2012/11/9
Y1 - 2012/11/9
N2 - Here we report the preparation, characterization and application of folic acid modified Montmorillonite clay (FA-Mont) as a cell culture material. Clays exhibit unique properties such as good mechanical and chemical stabilities, high surface area, low toxicity and easy combination with functional organic groups. FA was used as a modifier to facilitate adhesion of folate positive cells on the clay surface. FA-Mont was characterized using FT-IR, XRD, zeta potential measurements as well as thermogravimetric analyses. Finally, the usage potential of FA-Mont as a receptor mediated cell adhesion material was successfully proved by using folate receptor (FR) rich HeLa and FR poor A-549 cells. The cell adhesion studies were monitored and imaged by fluorescence and scanning electron microscopy techniques.
AB - Here we report the preparation, characterization and application of folic acid modified Montmorillonite clay (FA-Mont) as a cell culture material. Clays exhibit unique properties such as good mechanical and chemical stabilities, high surface area, low toxicity and easy combination with functional organic groups. FA was used as a modifier to facilitate adhesion of folate positive cells on the clay surface. FA-Mont was characterized using FT-IR, XRD, zeta potential measurements as well as thermogravimetric analyses. Finally, the usage potential of FA-Mont as a receptor mediated cell adhesion material was successfully proved by using folate receptor (FR) rich HeLa and FR poor A-549 cells. The cell adhesion studies were monitored and imaged by fluorescence and scanning electron microscopy techniques.
UR - http://www.scopus.com/inward/record.url?scp=84876539957&partnerID=8YFLogxK
U2 - 10.1039/c2tb00328g
DO - 10.1039/c2tb00328g
M3 - Article
C2 - 32260823
AN - SCOPUS:84876539957
VL - 1
SP - 522
EP - 528
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
SN - 2050-7518
IS - 4
ER -