Details
| Original language | English |
|---|---|
| Pages (from-to) | 3044-3052 |
| Number of pages | 9 |
| Journal | Chemistry - A European Journal |
| Volume | 22 |
| Issue number | 9 |
| Publication status | Published - 25 Jan 2016 |
Abstract
Inductively heated steel reactors continuously perform organic transformations in water under high temperature conditions, utilizing the unique physiochemical properties of water at subcritical conditions. We demonstrated the power of this set-up in the continuous synthesis of the atypical antipsychotic drug iloperidone, in which we performed four out of five steps under aqueous conditions.
Keywords
- flow synthesis, high temperature, industrial chemistry, medicinal chemistry, synthetic methods
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Organic Chemistry
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In: Chemistry - A European Journal, Vol. 22, No. 9, 25.01.2016, p. 3044-3052.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Flow Synthesis in Hot Water
T2 - Synthesis of the Atypical Antipsychotic Iloperidone
AU - Hartwig, Jan
AU - Kirschning, Andreas
PY - 2016/1/25
Y1 - 2016/1/25
N2 - Inductively heated steel reactors continuously perform organic transformations in water under high temperature conditions, utilizing the unique physiochemical properties of water at subcritical conditions. We demonstrated the power of this set-up in the continuous synthesis of the atypical antipsychotic drug iloperidone, in which we performed four out of five steps under aqueous conditions.
AB - Inductively heated steel reactors continuously perform organic transformations in water under high temperature conditions, utilizing the unique physiochemical properties of water at subcritical conditions. We demonstrated the power of this set-up in the continuous synthesis of the atypical antipsychotic drug iloperidone, in which we performed four out of five steps under aqueous conditions.
KW - flow synthesis
KW - high temperature
KW - industrial chemistry
KW - medicinal chemistry
KW - synthetic methods
UR - http://www.scopus.com/inward/record.url?scp=84960976369&partnerID=8YFLogxK
U2 - 10.1002/chem.201504409
DO - 10.1002/chem.201504409
M3 - Article
C2 - 25056998
AN - SCOPUS:84960976369
VL - 22
SP - 3044
EP - 3052
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
SN - 0947-6539
IS - 9
ER -