Details
| Original language | English |
|---|---|
| Pages (from-to) | 17-57 |
| Number of pages | 41 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 354 |
| Issue number | 1 |
| Publication status | Published - 12 Jan 2012 |
Abstract
Laboratory scaled flow-through processes have seen an explosive development over the past decade and have become an enabling technology for improving synthetic efficiency through automation and process optimization. Practically, flow devices are a crucial link between bench chemists and process engineers. The present review focuses on two unique aspects of modern flow chemistry where substantial advantages over the corresponding batch processes have become evident. Flow chemistry being one out of several enabling technologies can ideally be combined with other enabling technologies such as energy input. This may be achieved in form of heat to create supercritical conditions. Here, indirect methods such as microwave irradiation and inductive heating have seen widespread applications. Also radiation can efficiently be used to carry out photochemical reactions in a highly practical and scalable manner. A second unique aspect of flow chemistry compared to batch chemistry is associated with the option to carry out multistep synthesis by designing a flow set-up composed of several flow reactors. Besides their role as chemical reactors these can act as elements for purification or solvent switch.
Keywords
- Enabling technologies, Inductive heating, Micro reactors, Microwaves, Multicomponent reactions, Photochemistry
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Organic Chemistry
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In: Advanced Synthesis and Catalysis, Vol. 354, No. 1, 12.01.2012, p. 17-57.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Flow chemistry
T2 - A key enabling technology for (multistep) organic synthesis
AU - Wegner, Jens
AU - Ceylan, Sascha
AU - Kirschning, Andreas
PY - 2012/1/12
Y1 - 2012/1/12
N2 - Laboratory scaled flow-through processes have seen an explosive development over the past decade and have become an enabling technology for improving synthetic efficiency through automation and process optimization. Practically, flow devices are a crucial link between bench chemists and process engineers. The present review focuses on two unique aspects of modern flow chemistry where substantial advantages over the corresponding batch processes have become evident. Flow chemistry being one out of several enabling technologies can ideally be combined with other enabling technologies such as energy input. This may be achieved in form of heat to create supercritical conditions. Here, indirect methods such as microwave irradiation and inductive heating have seen widespread applications. Also radiation can efficiently be used to carry out photochemical reactions in a highly practical and scalable manner. A second unique aspect of flow chemistry compared to batch chemistry is associated with the option to carry out multistep synthesis by designing a flow set-up composed of several flow reactors. Besides their role as chemical reactors these can act as elements for purification or solvent switch.
AB - Laboratory scaled flow-through processes have seen an explosive development over the past decade and have become an enabling technology for improving synthetic efficiency through automation and process optimization. Practically, flow devices are a crucial link between bench chemists and process engineers. The present review focuses on two unique aspects of modern flow chemistry where substantial advantages over the corresponding batch processes have become evident. Flow chemistry being one out of several enabling technologies can ideally be combined with other enabling technologies such as energy input. This may be achieved in form of heat to create supercritical conditions. Here, indirect methods such as microwave irradiation and inductive heating have seen widespread applications. Also radiation can efficiently be used to carry out photochemical reactions in a highly practical and scalable manner. A second unique aspect of flow chemistry compared to batch chemistry is associated with the option to carry out multistep synthesis by designing a flow set-up composed of several flow reactors. Besides their role as chemical reactors these can act as elements for purification or solvent switch.
KW - Enabling technologies
KW - Inductive heating
KW - Micro reactors
KW - Microwaves
KW - Multicomponent reactions
KW - Photochemistry
UR - http://www.scopus.com/inward/record.url?scp=84856840761&partnerID=8YFLogxK
U2 - 10.1002/adsc.201100584
DO - 10.1002/adsc.201100584
M3 - Review article
AN - SCOPUS:84856840761
VL - 354
SP - 17
EP - 57
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
SN - 1615-4150
IS - 1
ER -