Details
| Original language | English |
|---|---|
| Pages (from-to) | 108-114 |
| Number of pages | 7 |
| Journal | Journal of Photochemistry and Photobiology A: Chemistry |
| Volume | 341 |
| Publication status | Published - 20 Mar 2017 |
| Externally published | Yes |
Abstract
Hyaluronic acid and poly(ethylene glycol) derivatives attract considerable attention as precursors for tissue engineering. In this paper photocuring of biocompatible hyaluronic acid-glycidyl methacrylate (HAGM) and poly(ethylene glycol) diacrylate (PEG-DA) aqueous solutions, using flavin mononucleotide (FMN) as an endogenous photoinitiator, has been studied. The required threshold concentrations of initial macromolecules in water for the strengthening (increase of the Young's modulus) of irradiated hydrogels have been determined as 57 wt% for 2D cross-linking of PEG-DA compositions and 16 wt% for 3D cross-linking of HAGM compositions. These concentrations are in a good agreement with correspondent values derived from the percolation theory for 2D and 3D lattices. It has been demonstrated that cross-linking proceeds predominantly by the radical mechanism and does not require co-initiators. Hydrogel scaffolds with specific and predetermined architectonics for biocompatibility and biomechanical studies have been produced by photopolymerizable micromolding.
Keywords
- Cross-linking, Flavin mononucleotide, Hyaluronic acid-glycidyl methacrylate, Hydrogel, Percolation, Poly(ethylene glycol) diacrylate
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Chemical Engineering(all)
- General Chemical Engineering
- Physics and Astronomy(all)
- General Physics and Astronomy
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In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 341, 20.03.2017, p. 108-114.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Flavin mononucleotide photoinitiated cross-linking of hydrogels
T2 - Polymer concentration threshold of strengthening
AU - Savelyev, Alexander G.
AU - Bardakova, Kseniia N.
AU - Khaydukov, Evgeny V.
AU - Generalova, Alla N.
AU - Popov, Vladimir K.
AU - Chichkov, Boris N.
AU - Semchishen, Vladimir A.
N1 - Funding information: The authors thank Dr. A. Koroleva (Lazer Zentrum Hannover) for making polydimethylsiloxane molds. This work was supported by the Russian Foundation for Basic Research [grant 14-29-10211] in a part of hydrogel formation and scaffold fabrication; Russian Science Foundation [project 14-13-01421] in a part of FMN (vitamin B2) photoinitiation mechanism study; and Russian Science Foundation [project 16-13-10528] in a part of HAGM synthesis.
PY - 2017/3/20
Y1 - 2017/3/20
N2 - Hyaluronic acid and poly(ethylene glycol) derivatives attract considerable attention as precursors for tissue engineering. In this paper photocuring of biocompatible hyaluronic acid-glycidyl methacrylate (HAGM) and poly(ethylene glycol) diacrylate (PEG-DA) aqueous solutions, using flavin mononucleotide (FMN) as an endogenous photoinitiator, has been studied. The required threshold concentrations of initial macromolecules in water for the strengthening (increase of the Young's modulus) of irradiated hydrogels have been determined as 57 wt% for 2D cross-linking of PEG-DA compositions and 16 wt% for 3D cross-linking of HAGM compositions. These concentrations are in a good agreement with correspondent values derived from the percolation theory for 2D and 3D lattices. It has been demonstrated that cross-linking proceeds predominantly by the radical mechanism and does not require co-initiators. Hydrogel scaffolds with specific and predetermined architectonics for biocompatibility and biomechanical studies have been produced by photopolymerizable micromolding.
AB - Hyaluronic acid and poly(ethylene glycol) derivatives attract considerable attention as precursors for tissue engineering. In this paper photocuring of biocompatible hyaluronic acid-glycidyl methacrylate (HAGM) and poly(ethylene glycol) diacrylate (PEG-DA) aqueous solutions, using flavin mononucleotide (FMN) as an endogenous photoinitiator, has been studied. The required threshold concentrations of initial macromolecules in water for the strengthening (increase of the Young's modulus) of irradiated hydrogels have been determined as 57 wt% for 2D cross-linking of PEG-DA compositions and 16 wt% for 3D cross-linking of HAGM compositions. These concentrations are in a good agreement with correspondent values derived from the percolation theory for 2D and 3D lattices. It has been demonstrated that cross-linking proceeds predominantly by the radical mechanism and does not require co-initiators. Hydrogel scaffolds with specific and predetermined architectonics for biocompatibility and biomechanical studies have been produced by photopolymerizable micromolding.
KW - Cross-linking
KW - Flavin mononucleotide
KW - Hyaluronic acid-glycidyl methacrylate
KW - Hydrogel
KW - Percolation
KW - Poly(ethylene glycol) diacrylate
UR - http://www.scopus.com/inward/record.url?scp=85016433397&partnerID=8YFLogxK
U2 - 10.1016/j.jphotochem.2017.03.026
DO - 10.1016/j.jphotochem.2017.03.026
M3 - Article
AN - SCOPUS:85016433397
VL - 341
SP - 108
EP - 114
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
SN - 1010-6030
ER -