Details
| Original language | English |
|---|---|
| Pages (from-to) | 2927-2930 |
| Number of pages | 4 |
| Journal | ChemBioChem |
| Volume | 21 |
| Issue number | 20 |
| Early online date | 2 Jun 2020 |
| Publication status | Published - 15 Oct 2020 |
Abstract
A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early building block as well as in the expression of two tailoring enzymes broadens the scope of chemo-biosynthetic access to new maytansinoids. Remarkably, a ring-expanded macrolactone derived from ansamitocin was created for the first time.
Keywords
- ansamitocin, macrolactones, maytansinoids, mutasynthesis, proansamitocins
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Medicine
- Biochemistry, Genetics and Molecular Biology(all)
- Molecular Biology
- Chemistry(all)
- Organic Chemistry
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In: ChemBioChem, Vol. 21, No. 20, 15.10.2020, p. 2927-2930.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - First ring-expanded maytansin lactone accessed by a new mutasynthetic variant
AU - Wesemann, Friederike
AU - Heutling, Anja
AU - Wienecke, Paul
AU - Kirschning, Andreas
PY - 2020/10/15
Y1 - 2020/10/15
N2 - A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early building block as well as in the expression of two tailoring enzymes broadens the scope of chemo-biosynthetic access to new maytansinoids. Remarkably, a ring-expanded macrolactone derived from ansamitocin was created for the first time.
AB - A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early building block as well as in the expression of two tailoring enzymes broadens the scope of chemo-biosynthetic access to new maytansinoids. Remarkably, a ring-expanded macrolactone derived from ansamitocin was created for the first time.
KW - ansamitocin
KW - macrolactones
KW - maytansinoids
KW - mutasynthesis
KW - proansamitocins
UR - http://www.scopus.com/inward/record.url?scp=85087292782&partnerID=8YFLogxK
U2 - 10.1002/cbic.202000336
DO - 10.1002/cbic.202000336
M3 - Article
C2 - 32484951
AN - SCOPUS:85087292782
VL - 21
SP - 2927
EP - 2930
JO - ChemBioChem
JF - ChemBioChem
SN - 1439-4227
IS - 20
ER -