Details
| Original language | English |
|---|---|
| Pages (from-to) | 686-687 |
| Number of pages | 2 |
| Journal | Chemical communications |
| Volume | 3 |
| Issue number | 6 |
| Publication status | Published - 1 Jan 2003 |
| Externally published | Yes |
Abstract
The minimal actinorhodin polyketide synthase bearing two point mutations (KSβ Q161A, ACP C17S) was chemically modified to carry novel C4 to C8 starter units on the ACP: on incubation with an excess of malonyl CoA new 16-carbon polyketides are made, supporting a measuring mechanism.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Ceramics and Composites
- Chemistry(all)
- General Chemistry
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Metals and Alloys
- Materials Science(all)
- Materials Chemistry
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In: Chemical communications, Vol. 3, No. 6, 01.01.2003, p. 686-687.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase
T2 - Evidence for the mechanism of chain length determination
AU - Nicholson, T. P.
AU - Winfield, C.
AU - Westcott, J.
AU - Crosby, J.
AU - Simpson, T. J.
AU - Cox, R. J.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - The minimal actinorhodin polyketide synthase bearing two point mutations (KSβ Q161A, ACP C17S) was chemically modified to carry novel C4 to C8 starter units on the ACP: on incubation with an excess of malonyl CoA new 16-carbon polyketides are made, supporting a measuring mechanism.
AB - The minimal actinorhodin polyketide synthase bearing two point mutations (KSβ Q161A, ACP C17S) was chemically modified to carry novel C4 to C8 starter units on the ACP: on incubation with an excess of malonyl CoA new 16-carbon polyketides are made, supporting a measuring mechanism.
UR - http://www.scopus.com/inward/record.url?scp=0037459418&partnerID=8YFLogxK
U2 - 10.1039/b300847a
DO - 10.1039/b300847a
M3 - Article
C2 - 12703773
AN - SCOPUS:0037459418
VL - 3
SP - 686
EP - 687
JO - Chemical communications
JF - Chemical communications
SN - 1359-7345
IS - 6
ER -