Details
| Original language | English |
|---|---|
| Pages (from-to) | 2115-2124 |
| Number of pages | 10 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 21 |
| Issue number | 7 |
| Publication status | Published - 9 Jun 2010 |
Abstract
Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-α-2,8-N-acetylneuraminic acid) a photoactive derivative (poly-α-2,8-N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biophysics
- Chemical Engineering(all)
- Bioengineering
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
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In: Journal of Materials Science: Materials in Medicine, Vol. 21, No. 7, 09.06.2010, p. 2115-2124.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration
AU - Assmann, Ulrike
AU - Szentivanyi, Andreas
AU - Stark, Yvonne
AU - Scheper, Thomas
AU - Berski, Silke
AU - Dräger, Gerald
AU - Schuster, Robert H.
N1 - Funding information: Acknowledgments This work was supported by DFG (Deutschen Forschungsgemeinschaft) and arose within the research group (FOR 548, ‘‘Polysialic acid: Towards the evaluation of a new bio-identical scaffold material’’). Helpful discussions with Stefanie Böhm and Cornelia Kasper (Institut für Technische Chemie, Universität Hannover) are grateful acknowledged.
PY - 2010/6/9
Y1 - 2010/6/9
N2 - Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-α-2,8-N-acetylneuraminic acid) a photoactive derivative (poly-α-2,8-N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells.
AB - Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-α-2,8-N-acetylneuraminic acid) a photoactive derivative (poly-α-2,8-N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells.
UR - http://www.scopus.com/inward/record.url?scp=77954533805&partnerID=8YFLogxK
U2 - 10.1007/s10856-010-4072-y
DO - 10.1007/s10856-010-4072-y
M3 - Article
C2 - 20532963
AN - SCOPUS:77954533805
VL - 21
SP - 2115
EP - 2124
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 7
ER -