Details
| Original language | English |
|---|---|
| Pages (from-to) | 6305-6312 |
| Number of pages | 8 |
| Journal | Journal of Nanoscience and Nanotechnology |
| Volume | 10 |
| Issue number | 10 |
| Publication status | Published - 1 Oct 2010 |
| Externally published | Yes |
Abstract
Microneedle devices for transdermal delivery of nanoscale pharmacologic agents were fabricated out of organically-modified ceramic (Ormocer ®) materials using two photon polymerization. Out-of-plane hollow microneedle arrays with various aspect ratios were fabricated using this rapid prototyping process. Human epidermal keratinocyte (HEK) viability on Ormocer ® surfaces fabricated using two photon polymerization was similar to that on control surfaces. Nanoindentation studies were performed to determine hardness and Young's modulus values for Ormocer ® materials. Microneedles were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration. Our results suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents.
Keywords
- Human epidermal keratinocytes, Microneedle, Nanomaterials, Rapid prototyping, Transdermal drug delivery
ASJC Scopus subject areas
- Chemical Engineering(all)
- Bioengineering
- Chemistry(all)
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- Physics and Astronomy(all)
- Condensed Matter Physics
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In: Journal of Nanoscience and Nanotechnology, Vol. 10, No. 10, 01.10.2010, p. 6305-6312.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Fabrication of microneedles using two photon polymerization for transdermal delivery of nanomaterials
AU - Doraiswamy, Anand
AU - Ovsianikov, Aleksandr
AU - Gittard, Shaun D.
AU - Monteiro-Riviere, Nancy A.
AU - Crombez, Rene
AU - Montalvo, Eva
AU - Shen, Weidian
AU - Chichkov, Boris N.
AU - Narayan, Roger J.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Microneedle devices for transdermal delivery of nanoscale pharmacologic agents were fabricated out of organically-modified ceramic (Ormocer ®) materials using two photon polymerization. Out-of-plane hollow microneedle arrays with various aspect ratios were fabricated using this rapid prototyping process. Human epidermal keratinocyte (HEK) viability on Ormocer ® surfaces fabricated using two photon polymerization was similar to that on control surfaces. Nanoindentation studies were performed to determine hardness and Young's modulus values for Ormocer ® materials. Microneedles were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration. Our results suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents.
AB - Microneedle devices for transdermal delivery of nanoscale pharmacologic agents were fabricated out of organically-modified ceramic (Ormocer ®) materials using two photon polymerization. Out-of-plane hollow microneedle arrays with various aspect ratios were fabricated using this rapid prototyping process. Human epidermal keratinocyte (HEK) viability on Ormocer ® surfaces fabricated using two photon polymerization was similar to that on control surfaces. Nanoindentation studies were performed to determine hardness and Young's modulus values for Ormocer ® materials. Microneedles were shown to enable more rapid distribution of the PEG-amine quantum dot solution to the deep epidermis and dermis layers of porcine skin than topical administration. Our results suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents.
KW - Human epidermal keratinocytes
KW - Microneedle
KW - Nanomaterials
KW - Rapid prototyping
KW - Transdermal drug delivery
UR - http://www.scopus.com/inward/record.url?scp=77949877695&partnerID=8YFLogxK
U2 - 10.1166/jnn.2010.2636
DO - 10.1166/jnn.2010.2636
M3 - Article
C2 - 21137723
AN - SCOPUS:77949877695
VL - 10
SP - 6305
EP - 6312
JO - Journal of Nanoscience and Nanotechnology
JF - Journal of Nanoscience and Nanotechnology
SN - 1533-4880
IS - 10
ER -