Details
| Original language | English |
|---|---|
| Article number | 4333 |
| Journal | Sensors (Switzerland) |
| Volume | 19 |
| Issue number | 19 |
| Publication status | Published - 1 Oct 2019 |
Abstract
Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.
Keywords
- 3D printing, Fluorescence, Hydrogels, Microfluidics, Waveguide
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Physics and Astronomy(all)
- Instrumentation
- Engineering(all)
- Electrical and Electronic Engineering
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In: Sensors (Switzerland), Vol. 19, No. 19, 4333, 01.10.2019.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Fabrication of a monolithic lab-on-a-chip platform with integrated hydrogel waveguides for chemical sensing
AU - Torres-Mapa, Maria Leilani
AU - Singh, Manmeet
AU - Simon, Olga
AU - Mapa, Jose Louise
AU - Machida, Manan
AU - Günther, Axel
AU - Roth, Bernhard
AU - Heinemann, Dag
AU - Terakawa, Mitsuhiro
AU - Heisterkamp, Alexander
N1 - Funding information: This work is supported by the Federal Ministry of Education and Research, Germany (13N14085) and the German Research Foundation, Germany Clusters of Excellence: REBIRTH (EXC 62) and Hearing4all (EXC 2177). Acknowledgments: The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover. We would like to acknowledge Kotaro Obata for early support on PDMS material and Manuel Fernandez for 3D-printing of the molds.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.
AB - Hydrogel waveguides have found increased use for variety of applications where biocompatibility and flexibility are important. In this work, we demonstrate the use of polyethylene glycol diacrylate (PEGDA) waveguides to realize a monolithic lab-on-a-chip device. We performed a comprehensive study on the swelling and optical properties for different chain lengths and concentrations in order to realize an integrated biocompatible waveguide in a microfluidic device for chemical sensing. Waveguiding properties of PEGDA hydrogel were used to guide excitation light into a microfluidic channel to measure the fluorescence emission profile of rhodamine 6G as well as collect the fluorescence signal from the same device. Overall, this work shows the potential of hydrogel waveguides to facilitate delivery and collection of optical signals for potential use in wearable and implantable lab-on-a-chip devices.
KW - 3D printing
KW - Fluorescence
KW - Hydrogels
KW - Microfluidics
KW - Waveguide
UR - http://www.scopus.com/inward/record.url?scp=85073097837&partnerID=8YFLogxK
U2 - 10.3390/s19194333
DO - 10.3390/s19194333
M3 - Article
C2 - 31597248
AN - SCOPUS:85073097837
VL - 19
JO - Sensors (Switzerland)
JF - Sensors (Switzerland)
SN - 1424-8220
IS - 19
M1 - 4333
ER -