Details
| Original language | English |
|---|---|
| Title of host publication | Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII |
| Publisher | SPIE |
| Pages | 477-487 |
| Number of pages | 11 |
| Publication status | Published - 12 Sept 2003 |
| Event | Biomedical Optics - San Jose, CA, United States Duration: 25 Jan 2003 → 31 Jan 2003 |
Publication series
| Name | Proceedings of SPIE - The International Society for Optical Engineering |
|---|---|
| Volume | 4949 |
| ISSN (Print) | 0277-786X |
Abstract
ELAN is a new method for treating atherosclerotic vessels. Its purpose is to restore wall flexibility by removing arterial wall tissue from the outer arterial layer. This leads to expansion of the narrowed vessel resulting in increased blood flow. We generated cuts in dissected arteries of sheep and pigs by photo-ablation with an ArF-Excimer Laser operating at a wavelength of 193 nm. During the cutting process the vessel diameter was monitored by measuring the running time of the laser induced pressure transients with a pressure transducer lying under the artery. A nearly linear increase of the diameter dependent on the residual wall thickness was found with a maximum increase of vessel diameter about 10 %. We also observed that the arterial wall maintains stable to very small residual wall thicknesses i.e. deep cutting. To support the experiments and to test different geometries of tissue removal we performed FEM-Analysis. We simulated vessel deformation and the total strain depending on the depth, width and number of cuts in the outer arterial wall. We also found a significant increase of the "lumen" in a model with atherosclerotic shape obtained from a histological section.
Keywords
- Atherosclerosis, ELAN, Excimer laser, FEM
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Condensed Matter Physics
- Computer Science(all)
- Computer Science Applications
- Mathematics(all)
- Applied Mathematics
- Engineering(all)
- Electrical and Electronic Engineering
Cite this
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Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII. SPIE, 2003. p. 477-487 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 4949).
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Extraluminal laser angioplasty (ELAN): a new method for treating atherosclerotic vessels
AU - Fabian Will, G.
AU - Singh, Ajoy
AU - Ertmer, Wolfgang
AU - Welling, Herbert
AU - Lubatschowski, Holger
PY - 2003/9/12
Y1 - 2003/9/12
N2 - ELAN is a new method for treating atherosclerotic vessels. Its purpose is to restore wall flexibility by removing arterial wall tissue from the outer arterial layer. This leads to expansion of the narrowed vessel resulting in increased blood flow. We generated cuts in dissected arteries of sheep and pigs by photo-ablation with an ArF-Excimer Laser operating at a wavelength of 193 nm. During the cutting process the vessel diameter was monitored by measuring the running time of the laser induced pressure transients with a pressure transducer lying under the artery. A nearly linear increase of the diameter dependent on the residual wall thickness was found with a maximum increase of vessel diameter about 10 %. We also observed that the arterial wall maintains stable to very small residual wall thicknesses i.e. deep cutting. To support the experiments and to test different geometries of tissue removal we performed FEM-Analysis. We simulated vessel deformation and the total strain depending on the depth, width and number of cuts in the outer arterial wall. We also found a significant increase of the "lumen" in a model with atherosclerotic shape obtained from a histological section.
AB - ELAN is a new method for treating atherosclerotic vessels. Its purpose is to restore wall flexibility by removing arterial wall tissue from the outer arterial layer. This leads to expansion of the narrowed vessel resulting in increased blood flow. We generated cuts in dissected arteries of sheep and pigs by photo-ablation with an ArF-Excimer Laser operating at a wavelength of 193 nm. During the cutting process the vessel diameter was monitored by measuring the running time of the laser induced pressure transients with a pressure transducer lying under the artery. A nearly linear increase of the diameter dependent on the residual wall thickness was found with a maximum increase of vessel diameter about 10 %. We also observed that the arterial wall maintains stable to very small residual wall thicknesses i.e. deep cutting. To support the experiments and to test different geometries of tissue removal we performed FEM-Analysis. We simulated vessel deformation and the total strain depending on the depth, width and number of cuts in the outer arterial wall. We also found a significant increase of the "lumen" in a model with atherosclerotic shape obtained from a histological section.
KW - Atherosclerosis
KW - ELAN
KW - Excimer laser
KW - FEM
UR - http://www.scopus.com/inward/record.url?scp=0141494343&partnerID=8YFLogxK
U2 - 10.1117/12.476269
DO - 10.1117/12.476269
M3 - Conference contribution
AN - SCOPUS:0141494343
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 477
EP - 487
BT - Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIII
PB - SPIE
T2 - Biomedical Optics
Y2 - 25 January 2003 through 31 January 2003
ER -