Details
| Original language | English |
|---|---|
| Article number | 1800092 |
| Number of pages | 12 |
| Journal | Advanced Therapeutics |
| Volume | 2 |
| Issue number | 1 |
| Publication status | Published - 10 Jan 2019 |
Abstract
Core-shell nanoparticles that exhibit superparamagnetic properties and stability as colloidal suspensions have been widely employed for medical imaging, diagnosis, and targeted drug delivery. These materials are engineered for spatial guidance using an external magnetic field and are capable of transporting therapeutic payloads such as clinical drugs and protein structures. They can be tagged with fluorescent dyes and quantum dots as spectroscopic markers; and can generate an acute influx of heat when exposed to an alternating magnetic field. When these functions are used in combination, core-shell nanoparticles can operate in a multimodal fashion, on demand, using external and non-invasive stimuli. In this short review, selected examples of externally induced drug release systems with magnetic nanoparticle carriers are highlighted. This new and emerging field of nanomedicine has enormous potential to advance our therapeutic capabilities with a central concept of targeting, locating, and detonating diseased and cancerous tissues in vivo with precise ex vivo control.
Keywords
- anticancer agents, drug release, iron oxide nanoparticles, nanomedicine, superparamagnetism
ASJC Scopus subject areas
- Medicine(all)
- Medicine (miscellaneous)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
- Medicine(all)
- Genetics(clinical)
- Medicine(all)
- Biochemistry, medical
- Medicine(all)
- Pharmacology (medical)
Sustainable Development Goals
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In: Advanced Therapeutics, Vol. 2, No. 1, 1800092, 10.01.2019.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Externally Induced Drug Release Systems with Magnetic Nanoparticle Carriers
T2 - An Emerging Field in Nanomedicine
AU - Norris, Matthew D.
AU - Seidel, Katja
AU - Kirschning, Andreas
PY - 2019/1/10
Y1 - 2019/1/10
N2 - Core-shell nanoparticles that exhibit superparamagnetic properties and stability as colloidal suspensions have been widely employed for medical imaging, diagnosis, and targeted drug delivery. These materials are engineered for spatial guidance using an external magnetic field and are capable of transporting therapeutic payloads such as clinical drugs and protein structures. They can be tagged with fluorescent dyes and quantum dots as spectroscopic markers; and can generate an acute influx of heat when exposed to an alternating magnetic field. When these functions are used in combination, core-shell nanoparticles can operate in a multimodal fashion, on demand, using external and non-invasive stimuli. In this short review, selected examples of externally induced drug release systems with magnetic nanoparticle carriers are highlighted. This new and emerging field of nanomedicine has enormous potential to advance our therapeutic capabilities with a central concept of targeting, locating, and detonating diseased and cancerous tissues in vivo with precise ex vivo control.
AB - Core-shell nanoparticles that exhibit superparamagnetic properties and stability as colloidal suspensions have been widely employed for medical imaging, diagnosis, and targeted drug delivery. These materials are engineered for spatial guidance using an external magnetic field and are capable of transporting therapeutic payloads such as clinical drugs and protein structures. They can be tagged with fluorescent dyes and quantum dots as spectroscopic markers; and can generate an acute influx of heat when exposed to an alternating magnetic field. When these functions are used in combination, core-shell nanoparticles can operate in a multimodal fashion, on demand, using external and non-invasive stimuli. In this short review, selected examples of externally induced drug release systems with magnetic nanoparticle carriers are highlighted. This new and emerging field of nanomedicine has enormous potential to advance our therapeutic capabilities with a central concept of targeting, locating, and detonating diseased and cancerous tissues in vivo with precise ex vivo control.
KW - anticancer agents
KW - drug release
KW - iron oxide nanoparticles
KW - nanomedicine
KW - superparamagnetism
UR - http://www.scopus.com/inward/record.url?scp=85096692506&partnerID=8YFLogxK
U2 - 10.1002/adtp.201800092
DO - 10.1002/adtp.201800092
M3 - Article
AN - SCOPUS:85096692506
VL - 2
JO - Advanced Therapeutics
JF - Advanced Therapeutics
IS - 1
M1 - 1800092
ER -