Details
| Original language | English |
|---|---|
| Pages (from-to) | 398-417 |
| Number of pages | 20 |
| Journal | FEMS microbiology reviews |
| Volume | 40 |
| Issue number | 3 |
| Publication status | Published - May 2016 |
Abstract
Protein modifications not only affect protein homeostasis but can also establish new cellular protein functions and are important components of complex cellular signal sensing and transduction networks. Among these post-translational modifications, protein phosphorylation represents the one that has been most thoroughly investigated. Unlike in eukarya, a large diversity of enzyme families has been shown to phosphorylate and dephosphorylate proteins on various amino acids with different chemical properties in bacteria. In this review, after a brief overview of the known bacterial phosphorylation systems, we focus on more recently discovered and less widely known kinases and phosphatases. Namely, we describe in detail tyrosine- and arginine-phosphorylation together with some examples of unusual serine-phosphorylation systems and discuss their potential role and function in bacterial physiology, and regulatory networks. Investigating these unusual bacterial kinase and phosphatases is not only important to understand their role in bacterial physiology but will help to generally understand the full potential and evolution of protein phosphorylation for signal transduction, protein modification and homeostasis in all cellular life.
Keywords
- Protein arginine phosphorylation, Protein homeostasis, Protein kinase/phosphatase, Protein modification, Protein serine/threonine phosphorylation, Protein-tyrosine phosphorylation
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Microbiology
- Medicine(all)
- Infectious Diseases
Sustainable Development Goals
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In: FEMS microbiology reviews, Vol. 40, No. 3, 05.2016, p. 398-417.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Exploring the diversity of protein modifications
T2 - Special bacterial phosphorylation systems
AU - Mijakovic, Ivan
AU - Grangeasse, Christophe
AU - Turgay, Kürşad
N1 - Publisher Copyright: © FEMS 2016. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/5
Y1 - 2016/5
N2 - Protein modifications not only affect protein homeostasis but can also establish new cellular protein functions and are important components of complex cellular signal sensing and transduction networks. Among these post-translational modifications, protein phosphorylation represents the one that has been most thoroughly investigated. Unlike in eukarya, a large diversity of enzyme families has been shown to phosphorylate and dephosphorylate proteins on various amino acids with different chemical properties in bacteria. In this review, after a brief overview of the known bacterial phosphorylation systems, we focus on more recently discovered and less widely known kinases and phosphatases. Namely, we describe in detail tyrosine- and arginine-phosphorylation together with some examples of unusual serine-phosphorylation systems and discuss their potential role and function in bacterial physiology, and regulatory networks. Investigating these unusual bacterial kinase and phosphatases is not only important to understand their role in bacterial physiology but will help to generally understand the full potential and evolution of protein phosphorylation for signal transduction, protein modification and homeostasis in all cellular life.
AB - Protein modifications not only affect protein homeostasis but can also establish new cellular protein functions and are important components of complex cellular signal sensing and transduction networks. Among these post-translational modifications, protein phosphorylation represents the one that has been most thoroughly investigated. Unlike in eukarya, a large diversity of enzyme families has been shown to phosphorylate and dephosphorylate proteins on various amino acids with different chemical properties in bacteria. In this review, after a brief overview of the known bacterial phosphorylation systems, we focus on more recently discovered and less widely known kinases and phosphatases. Namely, we describe in detail tyrosine- and arginine-phosphorylation together with some examples of unusual serine-phosphorylation systems and discuss their potential role and function in bacterial physiology, and regulatory networks. Investigating these unusual bacterial kinase and phosphatases is not only important to understand their role in bacterial physiology but will help to generally understand the full potential and evolution of protein phosphorylation for signal transduction, protein modification and homeostasis in all cellular life.
KW - Protein arginine phosphorylation
KW - Protein homeostasis
KW - Protein kinase/phosphatase
KW - Protein modification
KW - Protein serine/threonine phosphorylation
KW - Protein-tyrosine phosphorylation
UR - http://www.scopus.com/inward/record.url?scp=84975775571&partnerID=8YFLogxK
U2 - 10.1093/femsre/fuw003
DO - 10.1093/femsre/fuw003
M3 - Article
C2 - 26926353
AN - SCOPUS:84975775571
VL - 40
SP - 398
EP - 417
JO - FEMS microbiology reviews
JF - FEMS microbiology reviews
SN - 0168-6445
IS - 3
ER -