Details
| Translated title of the contribution | Erweiterung des synthetischen Potenzials von Sesquiterpencyclasen zur Erzeugung von nichtnatürlichen Terpenoiden |
|---|---|
| Original language | English |
| Pages (from-to) | 11802-11806 |
| Number of pages | 5 |
| Journal | Angewandte Chemie |
| Volume | 57 |
| Issue number | 36 |
| Early online date | 28 Jun 2018 |
| Publication status | Published - 27 Aug 2018 |
Abstract
The substrate flexibility of eight purified sesquiterpene cyclases was evaluated using six new heteroatom-modified farnesyl pyrophosphates, and the formation of six new heteroatom-modified macrocyclic and tricyclic sesquiterpenoids is described. GC-O analysis revealed that tricyclic tetrahydrofuran exhibits an ethereal, peppery, and camphor-like olfactoric scent.
Keywords
- biocatalysis, farnesyl pyrophosphates, scent compounds, terpene cyclases, terpenoids
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: Angewandte Chemie , Vol. 57, No. 36, 27.08.2018, p. 11802-11806.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Exploiting the Synthetic Potential of Sesquiterpene Cyclases for Generating Unnatural Terpenoids
AU - Oberhauser, Clara
AU - Harms, Vanessa
AU - Seidel, Katja
AU - Schröder, Benjamin
AU - Ekramzadeh, Kimia
AU - Beutel, Sascha
AU - Winkler, Sven
AU - Lauterbach, Lukas
AU - Dickschat, Jeroen S.
AU - Kirschning, Andreas
N1 - © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/8/27
Y1 - 2018/8/27
N2 - The substrate flexibility of eight purified sesquiterpene cyclases was evaluated using six new heteroatom-modified farnesyl pyrophosphates, and the formation of six new heteroatom-modified macrocyclic and tricyclic sesquiterpenoids is described. GC-O analysis revealed that tricyclic tetrahydrofuran exhibits an ethereal, peppery, and camphor-like olfactoric scent.
AB - The substrate flexibility of eight purified sesquiterpene cyclases was evaluated using six new heteroatom-modified farnesyl pyrophosphates, and the formation of six new heteroatom-modified macrocyclic and tricyclic sesquiterpenoids is described. GC-O analysis revealed that tricyclic tetrahydrofuran exhibits an ethereal, peppery, and camphor-like olfactoric scent.
KW - biocatalysis
KW - farnesyl pyrophosphates
KW - scent compounds
KW - terpene cyclases
KW - terpenoids
UR - http://www.scopus.com/inward/record.url?scp=85052522886&partnerID=8YFLogxK
U2 - 10.1002/anie.201805526
DO - 10.1002/anie.201805526
M3 - Article
C2 - 29953712
AN - SCOPUS:85052522886
VL - 57
SP - 11802
EP - 11806
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 36
ER -