Details
| Original language | English |
|---|---|
| Pages (from-to) | 781-783 |
| Number of pages | 3 |
| Journal | Natural product communications |
| Volume | 12 |
| Issue number | 5 |
| Publication status | Published - 1 May 2017 |
| Externally published | Yes |
Abstract
Further exploration of substrate diversity of the sansanmycin biosynthetic pathway using available halogen- and methyl-phenylalanines led to the generation of diverse sansanmycin derivatives, either at the single C- or N-terminus alone or at both C- and N-termini. The structures of all of these derivatives were determined by MS/MS spectra, and amongst them, the structures of [2-Cl-Phe]-sansanmycin H (1) and [2-Cl-Phe]-sansanmycin A (2) were further identified by NMR. Both the C-terminal derivative 1 and the N-terminal derivative 2 were assayed for their antibacterial activities, and compound 1 exhibited moderate activity against P. aeruginosa and ΔtolC mutant E. coli.
Keywords
- Antibacterial activity, NRPS, Sansanmycin, Substrate diversity
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Agricultural and Biological Sciences(all)
- Plant Science
- Medicine(all)
- Complementary and alternative medicine
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In: Natural product communications, Vol. 12, No. 5, 01.05.2017, p. 781-783.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Exploiting substrate diversity of NRPS Led to the generation of new sansanmycin analogs
AU - Wang, Shan Shan
AU - Zhang, Ning Ning
AU - He, Ning
AU - Guo, Wen Qiang
AU - Lei, Xuan
AU - Cai, Qiang
AU - Hong, Bin
AU - Xie, Yun Ying
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Further exploration of substrate diversity of the sansanmycin biosynthetic pathway using available halogen- and methyl-phenylalanines led to the generation of diverse sansanmycin derivatives, either at the single C- or N-terminus alone or at both C- and N-termini. The structures of all of these derivatives were determined by MS/MS spectra, and amongst them, the structures of [2-Cl-Phe]-sansanmycin H (1) and [2-Cl-Phe]-sansanmycin A (2) were further identified by NMR. Both the C-terminal derivative 1 and the N-terminal derivative 2 were assayed for their antibacterial activities, and compound 1 exhibited moderate activity against P. aeruginosa and ΔtolC mutant E. coli.
AB - Further exploration of substrate diversity of the sansanmycin biosynthetic pathway using available halogen- and methyl-phenylalanines led to the generation of diverse sansanmycin derivatives, either at the single C- or N-terminus alone or at both C- and N-termini. The structures of all of these derivatives were determined by MS/MS spectra, and amongst them, the structures of [2-Cl-Phe]-sansanmycin H (1) and [2-Cl-Phe]-sansanmycin A (2) were further identified by NMR. Both the C-terminal derivative 1 and the N-terminal derivative 2 were assayed for their antibacterial activities, and compound 1 exhibited moderate activity against P. aeruginosa and ΔtolC mutant E. coli.
KW - Antibacterial activity
KW - NRPS
KW - Sansanmycin
KW - Substrate diversity
UR - http://www.scopus.com/inward/record.url?scp=85019771271&partnerID=8YFLogxK
U2 - 10.1177/1934578x1701200524
DO - 10.1177/1934578x1701200524
M3 - Article
AN - SCOPUS:85019771271
VL - 12
SP - 781
EP - 783
JO - Natural product communications
JF - Natural product communications
SN - 1934-578X
IS - 5
ER -