Details
| Original language | English |
|---|---|
| Pages (from-to) | 198-204 |
| Number of pages | 7 |
| Journal | Laboratory animals |
| Volume | 43 |
| Issue number | 2 |
| Publication status | Published - 1 Apr 2009 |
Abstract
This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO2) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL (n = 131). The hearing level showed no significant difference before and after surgery (P < 0.05).
Keywords
- Brain response audiometry, Experimental middle ear surgery, Ossicular chain prostheses, Rabbit
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Animal Science and Zoology
- veterinary(all)
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In: Laboratory animals, Vol. 43, No. 2, 01.04.2009, p. 198-204.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Experimental middle ear surgery in rabbits
T2 - A new approach for reconstructing the ossicular chain
AU - Stieve, M.
AU - Hedrich, H. J.
AU - Battmer, R. D.
AU - Behrens, P.
AU - Müller, P.
AU - Lenarz, Th
PY - 2009/4/1
Y1 - 2009/4/1
N2 - This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO2) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL (n = 131). The hearing level showed no significant difference before and after surgery (P < 0.05).
AB - This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO2) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL (n = 131). The hearing level showed no significant difference before and after surgery (P < 0.05).
KW - Brain response audiometry
KW - Experimental middle ear surgery
KW - Ossicular chain prostheses
KW - Rabbit
UR - http://www.scopus.com/inward/record.url?scp=63849226025&partnerID=8YFLogxK
U2 - 10.1258/la.2008.007152
DO - 10.1258/la.2008.007152
M3 - Article
C2 - 19116292
AN - SCOPUS:63849226025
VL - 43
SP - 198
EP - 204
JO - Laboratory animals
JF - Laboratory animals
SN - 0023-6772
IS - 2
ER -