Details
| Original language | English |
|---|---|
| Pages (from-to) | 3027-3032 |
| Number of pages | 6 |
| Journal | CHEMCATCHEM |
| Volume | 5 |
| Issue number | 10 |
| Early online date | 3 Jul 2013 |
| Publication status | Published - Oct 2013 |
| Externally published | Yes |
Abstract
The laccase-mediator system (LMS) for the regeneration of oxidised nicotinamide co-factors was revisited to broaden the mediator scope. Among the 18 mediators screened, acetosyringone, syringaldehyde and caffeic acid excelled with respect to activity and stability under process conditions. The LMS based on the laccase from Myceliophthora thermophila and acetosyringone was further investigated and applied to promote the nicotinamide adenine dinucleotide (NAD+)-dependent oxidation of glucose as well as the oxidative lactonisation of 1,4-butanediol to the corresponding γ-butyrolactone. Laccase gets a look-in: The laccase-mediator system (LMS) for the regeneration of oxidized nicotinamide co-factors is revisited to broaden the mediator scope. The LMS based on the laccase from Myceliophthora thermophila and acetosyringone is applied to promote the oxidation of glucose and the oxidative lactonization of 1,4-butanediol to the corresponding γ-butyrolactone.
Keywords
- Biocatalysis, Cofactors, Enzyme catalysis, Lactones, Oxidation
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
- Chemistry(all)
- Inorganic Chemistry
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In: CHEMCATCHEM, Vol. 5, No. 10, 10.2013, p. 3027-3032.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Expanding the scope of laccase-mediator systems
AU - Könst, Paul
AU - Kara, Selin
AU - Kochius, Svenja
AU - Holtmann, Dirk
AU - Arends, Isabel W.C.E.
AU - Ludwig, Roland
AU - Hollmann, Frank
PY - 2013/10
Y1 - 2013/10
N2 - The laccase-mediator system (LMS) for the regeneration of oxidised nicotinamide co-factors was revisited to broaden the mediator scope. Among the 18 mediators screened, acetosyringone, syringaldehyde and caffeic acid excelled with respect to activity and stability under process conditions. The LMS based on the laccase from Myceliophthora thermophila and acetosyringone was further investigated and applied to promote the nicotinamide adenine dinucleotide (NAD+)-dependent oxidation of glucose as well as the oxidative lactonisation of 1,4-butanediol to the corresponding γ-butyrolactone. Laccase gets a look-in: The laccase-mediator system (LMS) for the regeneration of oxidized nicotinamide co-factors is revisited to broaden the mediator scope. The LMS based on the laccase from Myceliophthora thermophila and acetosyringone is applied to promote the oxidation of glucose and the oxidative lactonization of 1,4-butanediol to the corresponding γ-butyrolactone.
AB - The laccase-mediator system (LMS) for the regeneration of oxidised nicotinamide co-factors was revisited to broaden the mediator scope. Among the 18 mediators screened, acetosyringone, syringaldehyde and caffeic acid excelled with respect to activity and stability under process conditions. The LMS based on the laccase from Myceliophthora thermophila and acetosyringone was further investigated and applied to promote the nicotinamide adenine dinucleotide (NAD+)-dependent oxidation of glucose as well as the oxidative lactonisation of 1,4-butanediol to the corresponding γ-butyrolactone. Laccase gets a look-in: The laccase-mediator system (LMS) for the regeneration of oxidized nicotinamide co-factors is revisited to broaden the mediator scope. The LMS based on the laccase from Myceliophthora thermophila and acetosyringone is applied to promote the oxidation of glucose and the oxidative lactonization of 1,4-butanediol to the corresponding γ-butyrolactone.
KW - Biocatalysis
KW - Cofactors
KW - Enzyme catalysis
KW - Lactones
KW - Oxidation
UR - http://www.scopus.com/inward/record.url?scp=84884947705&partnerID=8YFLogxK
U2 - 10.1002/cctc.201300205
DO - 10.1002/cctc.201300205
M3 - Article
AN - SCOPUS:84884947705
VL - 5
SP - 3027
EP - 3032
JO - CHEMCATCHEM
JF - CHEMCATCHEM
SN - 1867-3880
IS - 10
ER -