Details
| Original language | English |
|---|---|
| Article number | e003651 |
| Journal | Circulation: Cardiovascular Imaging |
| Volume | 8 |
| Issue number | 12 |
| Publication status | Published - Dec 2015 |
| Externally published | Yes |
Abstract
Background - Contemporary understanding of exercise-induced cardiac remodeling is based on cross-sectional data and relatively short duration longitudinal studies. Temporal progression of exercise-induced cardiac remodeling remains incompletely understood. Methods and Results - A longitudinal repeated-measures study design using 2-dimensional and speckle-tracking echocardiography was used to examine acute augmentation phase (AAP; 90 days) and more extended chronic maintenance phase (39 months) left ventricular (LV) structural and functional adaptations to endurance exercise training among competitive male rowers (n=12; age 18.6±0.5 years). LV mass was within normal limits at baseline (93±9 g/m2), increased after AAP (105±7 g/m2; P=0.001), and further increased after chronic maintenance phase (113±10 g/m2; P<0.001 for comparison to post-AAP). AAP LV hypertrophy was driven by LV dilation (ΔLV end-diastolic volume, 9±3 mL/m2; P=0.004) with stable LV wall thickness (ΔLV wall thickness, 0.3±0.1 mm; P=0.63). In contrast, chronic maintenance phase LV hypertrophy was attributable to LV wall thickening (Δ LV wall thickness, 1.1±0.4 mm; P=0.004) with stable LV chamber volumes (ΔLV end-diastolic volume, 1±1 mL/m2; P=0.48). Early diastolic peak tissue velocity increased during AAP (-11.7±1.9 versus -13.6±1.3 cm/s; P<0.001) and remained similarly increased after chronic maintenance phase. Conclusions - In a small sample of competitive endurance athletes, exercise-induced cardiac remodeling follows a phasic response with increases in LV chamber size, early diastolic function, and systolic twist in an acute augmentation phase of exercise training. This is followed by a chronic phase of adaptation characterized by increasing wall thickness and regression in LV twist. Training duration is a determinant of exercise-induced cardiac remodeling and has implications for the assessment of myocardial structure and function in athletes.
Keywords
- echocardiography, exercise, hypertrophy, left ventricular, longitudinal studies, myocardium
ASJC Scopus subject areas
- Medicine(all)
- Radiology Nuclear Medicine and imaging
- Medicine(all)
- Cardiology and Cardiovascular Medicine
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In: Circulation: Cardiovascular Imaging, Vol. 8, No. 12, e003651, 12.2015.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Exercise-Induced Left Ventricular Remodeling among Competitive Athletes
T2 - A Phasic Phenomenon
AU - Weiner, Rory B.
AU - Deluca, James R.
AU - Wang, Francis
AU - Lin, Jeffrey
AU - Wasfy, Meagan M.
AU - Berkstresser, Brant
AU - Stöhr, Eric
AU - Shave, Rob
AU - Lewis, Gregory D.
AU - Hutter, Adolph M.
AU - Picard, Michael H.
AU - Baggish, Aaron L.
PY - 2015/12
Y1 - 2015/12
N2 - Background - Contemporary understanding of exercise-induced cardiac remodeling is based on cross-sectional data and relatively short duration longitudinal studies. Temporal progression of exercise-induced cardiac remodeling remains incompletely understood. Methods and Results - A longitudinal repeated-measures study design using 2-dimensional and speckle-tracking echocardiography was used to examine acute augmentation phase (AAP; 90 days) and more extended chronic maintenance phase (39 months) left ventricular (LV) structural and functional adaptations to endurance exercise training among competitive male rowers (n=12; age 18.6±0.5 years). LV mass was within normal limits at baseline (93±9 g/m2), increased after AAP (105±7 g/m2; P=0.001), and further increased after chronic maintenance phase (113±10 g/m2; P<0.001 for comparison to post-AAP). AAP LV hypertrophy was driven by LV dilation (ΔLV end-diastolic volume, 9±3 mL/m2; P=0.004) with stable LV wall thickness (ΔLV wall thickness, 0.3±0.1 mm; P=0.63). In contrast, chronic maintenance phase LV hypertrophy was attributable to LV wall thickening (Δ LV wall thickness, 1.1±0.4 mm; P=0.004) with stable LV chamber volumes (ΔLV end-diastolic volume, 1±1 mL/m2; P=0.48). Early diastolic peak tissue velocity increased during AAP (-11.7±1.9 versus -13.6±1.3 cm/s; P<0.001) and remained similarly increased after chronic maintenance phase. Conclusions - In a small sample of competitive endurance athletes, exercise-induced cardiac remodeling follows a phasic response with increases in LV chamber size, early diastolic function, and systolic twist in an acute augmentation phase of exercise training. This is followed by a chronic phase of adaptation characterized by increasing wall thickness and regression in LV twist. Training duration is a determinant of exercise-induced cardiac remodeling and has implications for the assessment of myocardial structure and function in athletes.
AB - Background - Contemporary understanding of exercise-induced cardiac remodeling is based on cross-sectional data and relatively short duration longitudinal studies. Temporal progression of exercise-induced cardiac remodeling remains incompletely understood. Methods and Results - A longitudinal repeated-measures study design using 2-dimensional and speckle-tracking echocardiography was used to examine acute augmentation phase (AAP; 90 days) and more extended chronic maintenance phase (39 months) left ventricular (LV) structural and functional adaptations to endurance exercise training among competitive male rowers (n=12; age 18.6±0.5 years). LV mass was within normal limits at baseline (93±9 g/m2), increased after AAP (105±7 g/m2; P=0.001), and further increased after chronic maintenance phase (113±10 g/m2; P<0.001 for comparison to post-AAP). AAP LV hypertrophy was driven by LV dilation (ΔLV end-diastolic volume, 9±3 mL/m2; P=0.004) with stable LV wall thickness (ΔLV wall thickness, 0.3±0.1 mm; P=0.63). In contrast, chronic maintenance phase LV hypertrophy was attributable to LV wall thickening (Δ LV wall thickness, 1.1±0.4 mm; P=0.004) with stable LV chamber volumes (ΔLV end-diastolic volume, 1±1 mL/m2; P=0.48). Early diastolic peak tissue velocity increased during AAP (-11.7±1.9 versus -13.6±1.3 cm/s; P<0.001) and remained similarly increased after chronic maintenance phase. Conclusions - In a small sample of competitive endurance athletes, exercise-induced cardiac remodeling follows a phasic response with increases in LV chamber size, early diastolic function, and systolic twist in an acute augmentation phase of exercise training. This is followed by a chronic phase of adaptation characterized by increasing wall thickness and regression in LV twist. Training duration is a determinant of exercise-induced cardiac remodeling and has implications for the assessment of myocardial structure and function in athletes.
KW - echocardiography
KW - exercise
KW - hypertrophy, left ventricular
KW - longitudinal studies
KW - myocardium
UR - http://www.scopus.com/inward/record.url?scp=84951045296&partnerID=8YFLogxK
U2 - 10.1161/CIRCIMAGING.115.003651
DO - 10.1161/CIRCIMAGING.115.003651
M3 - Article
C2 - 26666381
AN - SCOPUS:84951045296
VL - 8
JO - Circulation: Cardiovascular Imaging
JF - Circulation: Cardiovascular Imaging
SN - 1941-9651
IS - 12
M1 - e003651
ER -