Details
| Original language | English |
|---|---|
| Title of host publication | Enzyme Cascade Design and Modelling |
| Editors | Selin Kara, Florian Rudroff |
| Chapter | 7 |
| Pages | 109-124 |
| Number of pages | 16 |
| ISBN (electronic) | 978-3-030-65718-5 |
| Publication status | Published - 2021 |
| Externally published | Yes |
Abstract
Biocatalytic transformations are of growing interest due to their high chemo-, regio-, and enantioselectivity, sustainability, and biocompatibility. In order to build on these advantages, to reinforce them, and not to weaken them, as well as to ensure the fulfillment of economic framework conditions, it is important to harmonize the reaction with its best suitable reactor and operation mode. In this chapter, three ideal reactor types and their biocatalytic conversion equations are presented for different inhibition scenarios, facilitating the proper bioreactor selection. Important aspects in the implementation of an enzymatic cascade are discussed and the introduced equations are exemplarily illustrated for a cascade reaction. In order to highlight different emerging approaches for cascade engineering, miniaturized flow bioreactors are discussed, and examples of recent publications are presented.
Keywords
- Enzymatic process optimization, Enzyme cascades, Flow biocatalysis, Kinetic modelling, Michaelis-Menten kinetics, Reactor configurations
ASJC Scopus subject areas
- Engineering(all)
- General Engineering
- Chemical Engineering(all)
- General Chemical Engineering
- Chemistry(all)
- General Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- General Biochemistry,Genetics and Molecular Biology
Cite this
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Enzyme Cascade Design and Modelling. ed. / Selin Kara; Florian Rudroff. 2021. p. 109-124.
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research
}
TY - CHAP
T1 - Enzyme Cascade Reaction Engineering
AU - Petermeier, Philipp
AU - Kara, Selin
PY - 2021
Y1 - 2021
N2 - Biocatalytic transformations are of growing interest due to their high chemo-, regio-, and enantioselectivity, sustainability, and biocompatibility. In order to build on these advantages, to reinforce them, and not to weaken them, as well as to ensure the fulfillment of economic framework conditions, it is important to harmonize the reaction with its best suitable reactor and operation mode. In this chapter, three ideal reactor types and their biocatalytic conversion equations are presented for different inhibition scenarios, facilitating the proper bioreactor selection. Important aspects in the implementation of an enzymatic cascade are discussed and the introduced equations are exemplarily illustrated for a cascade reaction. In order to highlight different emerging approaches for cascade engineering, miniaturized flow bioreactors are discussed, and examples of recent publications are presented.
AB - Biocatalytic transformations are of growing interest due to their high chemo-, regio-, and enantioselectivity, sustainability, and biocompatibility. In order to build on these advantages, to reinforce them, and not to weaken them, as well as to ensure the fulfillment of economic framework conditions, it is important to harmonize the reaction with its best suitable reactor and operation mode. In this chapter, three ideal reactor types and their biocatalytic conversion equations are presented for different inhibition scenarios, facilitating the proper bioreactor selection. Important aspects in the implementation of an enzymatic cascade are discussed and the introduced equations are exemplarily illustrated for a cascade reaction. In order to highlight different emerging approaches for cascade engineering, miniaturized flow bioreactors are discussed, and examples of recent publications are presented.
KW - Enzymatic process optimization
KW - Enzyme cascades
KW - Flow biocatalysis
KW - Kinetic modelling
KW - Michaelis-Menten kinetics
KW - Reactor configurations
UR - http://www.scopus.com/inward/record.url?scp=85110449502&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-65718-5_7
DO - 10.1007/978-3-030-65718-5_7
M3 - Contribution to book/anthology
SN - 978-3-030-65717-8
SP - 109
EP - 124
BT - Enzyme Cascade Design and Modelling
A2 - Kara, Selin
A2 - Rudroff, Florian
ER -