Details
| Original language | English |
|---|---|
| Pages (from-to) | 4983-4997 |
| Number of pages | 15 |
| Journal | CHEMCATCHEM |
| Volume | 11 |
| Issue number | 20 |
| Early online date | 25 Jul 2019 |
| Publication status | Published - 22 Oct 2019 |
| Externally published | Yes |
Abstract
Biodegradable polymers such as polylactides and other polylactones and their synthesis gain progressively importance. Enzymatic ring-opening polymerization (eROP) is the next step sustainable synthesis of polyesters, also suitable for biomedical applications due to high selectivity and lack of toxic agents. The possibility for applying diverse reaction media ranging from traditional bulk and organic media to greener alternatives such as aqueous media, ionic liquids, and supercritical fluids may allow designing alternative non-conventional processes with less environmental footprint. Target success criteria such as high molecular weight and uniformity of polymers, and conversion of monomers have to be carefully evaluated in these diverse media. Herein we discuss the influence of different reaction media and conditions such as water content, temperature and time on the polymer sizes achieved in eROPs and various approaches to improve the molecular weight and uniformity of polymers.
Keywords
- Enzymatic polymerizations, Enzymatic polymerizations in aqueous media, Enzymatic polymerizations in organic media, Ring opening polymerization
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
- Chemistry(all)
- Inorganic Chemistry
Sustainable Development Goals
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In: CHEMCATCHEM, Vol. 11, No. 20, 22.10.2019, p. 4983-4997.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Enzymatic Ring-Opening Polymerization of Lactones
T2 - Traditional Approaches and Alternative Strategies
AU - Engel, Jennifer
AU - Cordellier, Alex
AU - Huang, Lei
AU - Kara, Selin
N1 - Funding Information: J.E., L.H. and S.K. thank to Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) for the financial support (grant no AOBJ 650427 (KA 4399/1-1) and grant no AOBJ 655719 (KA 4399/1-1)). A.C. and S.K. gratefully acknowledge the financial support from the European Union's Horizon 2020 research and innovation program under the Marie Sk?odowska-Curie Actions (grant no 764920).
PY - 2019/10/22
Y1 - 2019/10/22
N2 - Biodegradable polymers such as polylactides and other polylactones and their synthesis gain progressively importance. Enzymatic ring-opening polymerization (eROP) is the next step sustainable synthesis of polyesters, also suitable for biomedical applications due to high selectivity and lack of toxic agents. The possibility for applying diverse reaction media ranging from traditional bulk and organic media to greener alternatives such as aqueous media, ionic liquids, and supercritical fluids may allow designing alternative non-conventional processes with less environmental footprint. Target success criteria such as high molecular weight and uniformity of polymers, and conversion of monomers have to be carefully evaluated in these diverse media. Herein we discuss the influence of different reaction media and conditions such as water content, temperature and time on the polymer sizes achieved in eROPs and various approaches to improve the molecular weight and uniformity of polymers.
AB - Biodegradable polymers such as polylactides and other polylactones and their synthesis gain progressively importance. Enzymatic ring-opening polymerization (eROP) is the next step sustainable synthesis of polyesters, also suitable for biomedical applications due to high selectivity and lack of toxic agents. The possibility for applying diverse reaction media ranging from traditional bulk and organic media to greener alternatives such as aqueous media, ionic liquids, and supercritical fluids may allow designing alternative non-conventional processes with less environmental footprint. Target success criteria such as high molecular weight and uniformity of polymers, and conversion of monomers have to be carefully evaluated in these diverse media. Herein we discuss the influence of different reaction media and conditions such as water content, temperature and time on the polymer sizes achieved in eROPs and various approaches to improve the molecular weight and uniformity of polymers.
KW - Enzymatic polymerizations
KW - Enzymatic polymerizations in aqueous media
KW - Enzymatic polymerizations in organic media
KW - Ring opening polymerization
UR - http://www.scopus.com/inward/record.url?scp=85073689682&partnerID=8YFLogxK
U2 - 10.1002/cctc.201900976
DO - 10.1002/cctc.201900976
M3 - Review article
AN - SCOPUS:85073689682
VL - 11
SP - 4983
EP - 4997
JO - CHEMCATCHEM
JF - CHEMCATCHEM
SN - 1867-3880
IS - 20
ER -